{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:01:08Z","timestamp":1787907668822,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T00:00:00Z","timestamp":1331510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative analgesic effect of a perioperative fixed dose glucocorticoid has been demonstrated in studies on different surgical procedures. The aim of this study was to look for analgesic and opioid sparing effect after thyroid surgery with a weight\u2010adjusted medium dose of dexamethasone compared with placebo or a higher dose. Further, to register other effects and side effects of dexamethasone in the 0\u201330 days post\u2010operative period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients scheduled for thyroid surgery were randomly assigned to three groups receiving either dexamethasone 0.30\u2009mg\/kg, 0.15\u2009mg\/kg or placebo. Pain scores at rest and on coughing, post\u2010operative nausea and vomiting (<jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content>), consumption of opioids and anti\u2010emetics, appetite, sleep pattern, fatigue, mood, blood sugar, wound infection and dyspepsia were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no effect of either dexamethasone doses on post\u2010operative pain or rescue opioid consumption. <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> was lower in the dexamethasone groups 2\u20134\u2009h post\u2010operatively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01). Blood sugar increased moderately from baseline in all groups, but significantly more in the dexamethasone groups (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01 at 2\u2009h and <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001 at 4\u2009h). Minor improvement in appetite was shown with dexamethasone, along with a tendency towards less sleep and more fatigue in the 3\u201330 days period for the higher dose. No effect was demonstrated on other parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dexamethasone had no analgesic or opioid sparing effect in our set\u2010up after thyroid surgery. Dexamethasone reduced the incidence of <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> and led to a modest increase in blood sugar. A medium dose seems as effective as a higher dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02654.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T10:43:43Z","timestamp":1331549023000},"page":"513-519","source":"Crossref","is-referenced-by-count":28,"title":["Dexamethasone does not reduce pain or analgesic consumption after thyroid surgery; a prospective, randomized trial"],"prefix":"10.1111","volume":"56","author":[{"given":"S.","family":"DOKSR\u00d8D","sequence":"first","affiliation":[{"name":"Departement of Anaesthesiology Telemark Hospital  Skien Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8.","family":"SAGEN","sequence":"additional","affiliation":[{"name":"Departement of Anaesthesiology Telemark Hospital  Skien Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"N\u00d8STDAHL","sequence":"additional","affiliation":[{"name":"Departement of Anaesthesiology Telemark Hospital  Skien Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"R\u00c6DER","sequence":"additional","affiliation":[{"name":"Departement of Anaesthesiology Oslo University Hospital, Ullevaal \u2013 Oslo, Norway and Clinical Division, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31822a24c2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818c709a"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2005.11679742"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01141.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000094390.82352.cb"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2006.01240.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.04.022"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159a5cc"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510012327"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01650.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000063922.90966.3A"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000194358.46119.e1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199808000-00015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200012000-00019"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000267261.61444.69"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200001000-00038"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000105875.05357.A0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181b0f0bb"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2005.05.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328319c09b"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2012.02654.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2012.02654.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:43:06Z","timestamp":1698712986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2012.02654.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1399-6576.2012.02654.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2012.02654.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,12]]}}}