{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:05:31Z","timestamp":1781715931398,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Background<\/jats:title>Recently, local infiltration analgesia (LIA<\/jats:styled-content>) has been promoted for pain control after total hip arthroplasty (THA<\/jats:styled-content>). We hypothesized that LIA<\/jats:styled-content> would offer equal analgesic efficacy but less adverse effects, e.g., nausea and vomiting, when compared with an established regimen [intrathecal morphine (it\u2010M<\/jats:styled-content>)] after THA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>This randomized controlled trial comprised 60 patients undergoing THA<\/jats:styled-content> under spinal anaesthesia. For LIA<\/jats:styled-content>, the surgeon administered levobupivacaine, ketorolac and epinephrine at the surgical site intraoperatively. LIA<\/jats:styled-content> patients received a LIA<\/jats:styled-content> top\u2010up through a wound catheter on the morning of the 1st post\u2010operative day (POD<\/jats:styled-content>). In group it\u2010M<\/jats:styled-content>, 0.1\u2009mg morphine was given together with the spinal anaesthetic. Study parameters included pain scores, vital parameters and side effects, e.g., post\u2010operative nausea and vomiting (PONV<\/jats:styled-content>). Besides, levobupivacaine plasma concentrations were determined in 10 LIA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Results<\/jats:title>The median (25th\/75th percentiles) rescue oxycodone demand differed significantly with LIA<\/jats:styled-content> 15 (10\/25)\u2009mg vs. 8.5 (1.5\/15)\u2009mg with it\u2010M<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.006) during the day of surgery, but not anymore on 1st or 2nd POD<\/jats:styled-content>. The LIA<\/jats:styled-content> top\u2010up had no effect. However, both analgesic regimens resulted in comparable pain scores and patient satisfaction. PONV<\/jats:styled-content> incidence and medication did not vary significantly. LIA<\/jats:styled-content> offered certain advantages regarding early post\u2010operative mobilization. Maximum levobupivacaine plasma concentrations (229\u2013580\u2009ng\/ml) remained under the toxic level.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>While LIA<\/jats:styled-content> might enable earlier mobilization after THA<\/jats:styled-content>, it was not associated with less nausea as compared with it\u2010M<\/jats:styled-content>. Less rescue oxycodone was given early after it\u2010M<\/jats:styled-content>, but urinary retention was more common in that group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02667.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T16:12:17Z","timestamp":1331136737000},"page":"695-705","source":"Crossref","is-referenced-by-count":38,"title":["Local infiltration analgesia with levobupivacaine compared with intrathecal morphine in total hip arthroplasty patients"],"prefix":"10.1111","volume":"56","author":[{"given":"R.","family":"RIKALAINEN\u2010SALMI","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"F\u00d6RSTER","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Orton Orthopaedic Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"M\u00c4KEL\u00c4","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"VIROLAINEN","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"LEINO","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"PITK\u00c4NEN","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Orton Orthopaedic Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"NEUVONEN","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki and HUSLAB, Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"KUUSNIEMI","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine Turku University Hospital Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200201000-00025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20100722-65"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200509000-00006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199907000-00006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014950"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710013627"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710013663"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710013654"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710013645"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01777.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02429.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/55.5.415"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1213\/00000539-199904000-00026","article-title":"Optimization of the dose of intrathecal morphine in total hip surgery: a dose\u2010finding study","volume":"88","author":"Slappendel R","year":"1999","journal-title":"Anesth Analg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-022X(03)00099-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182288deb"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.01043.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2011.596063"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1198-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3182186866"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318228e295"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2011.570671"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2005.01.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018643"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00775.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453671003685400"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.89B12.18969"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00870"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453670902930008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200605000-00005"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2012.02667.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2012.02667.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T17:54:12Z","timestamp":1698774852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2012.02667.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,7]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1399-6576.2012.02667.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2012.02667.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,7]]}}}