{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:12:21Z","timestamp":1790849541007,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Studies are inconclusive regarding clinical outcomes after administration of recombinant activated coagulation factor <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content>) during severe haemorrhage. The circumstances encountered during desperate haemorrhage make it difficult to include the most critically ill patients that could possibly benefit the most from such treatment into randomized controlled trials. We report our experience with <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> as last\u2010resort treatment of desperate haemorrhage when all standard treatment has failed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Hospital charts of all consecutive patients treated with <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> for desperate non\u2010haemophilic bleeding over a 10\u2010year period at the single institution administering <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> were surveyed for treatment indications, clinical outcome, transfusion need and coagulation profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> treatment occasions of desperate bleeding were identified in 54 patients (median age 54 years). A single <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> dose was used in 86%, and haemorrhage was considered effectively contained by immediate clinical response on 81% of occasions. Overall, 38 patients (71%) survived for over 30 days. Two thromboembolic events occurred (3.6%). The 24\u2010h mortality in 45 <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> immediate clinical responders and 10 non\u2010responders was 2% and 50%, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0004), and the 30\u2010day mortality was 25% and 60%, respectively (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.05). Blood product use decreased with <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01) as did the prothrombin time (20.0\u201013.3\u2009s, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of unselected consecutive patients receiving <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> as last\u2010resort treatment for desperate haemorrhage were considered to have immediate clinical response as well as reduced transfusion requirements and correction of coagulation parameters. An immediate clinical response to <jats:styled-content style=\"fixed-case\">rFVIIa<\/jats:styled-content> may possibly be predictive of survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02688.x","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T12:38:29Z","timestamp":1334061509000},"page":"636-644","source":"Crossref","is-referenced-by-count":14,"title":["Recombinant factor <scp>VIIa<\/scp> as last\u2010resort treatment of desperate haemorrhage"],"prefix":"10.1111","volume":"56","author":[{"given":"R.","family":"PALMASON","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Landspitali\u2010University Hospital  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"VIDARSSON","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Landspitali\u2010University Hospital  Reykjavik Iceland"},{"name":"Department of Laboratory Hematology and Coagulation Disorders Landspitali\u2010University Hospital  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"SIGVALDASON","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Landspitali\u2010University Hospital  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"INGIMARSSON","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Landspitali\u2010University Hospital  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"GUDBJARTSSON","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Landspitali\u2010University Hospital  Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"SIGURDSSON","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology and Coagulation Disorders Landspitali\u2010University Hospital  Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. T.","family":"ONUNDARSON","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology and Coagulation Disorders Landspitali\u2010University Hospital  Reykjavik Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(03)90000-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.01.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02352.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05155-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609335909"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029607308863"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04216.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.10.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000171470.39742.8E"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.10.033"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.834275"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000171453.37949.B7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181edf36e"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-8-201104190-00004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318176c4ec"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100408"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1006221"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613879"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02289.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12268-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707534"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.05.062"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20458"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200502000-00006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei244"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-006-1032-5"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000135142.80368.65"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203078"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20101027"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.5.755"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1718-7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000162449.55887.B9"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181cc4378"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c039e6"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/364843"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2012.02688.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2012.02688.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T14:21:53Z","timestamp":1697379713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2012.02688.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,10]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1399-6576.2012.02688.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2012.02688.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,10]]}}}