{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:53:43Z","timestamp":1758970423513},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to investigate the effect of general anaesthesia induced by isoflurane with buprenorphine on hippocampus\u2010dependent and neocortex\u2010dependent memory, respectively, in mice, and in addition, to compare the effects of such anaesthesia on these memory processes with the effects induced by lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) administration on the same memory processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To assess hippocampus\u2010dependent memory, isoflurane (for 15\u2009min) after buprenorphine injection, or <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> 100\u2009\u03bcg\/kg (intraperitoneally) was administered 24\u2009h before or after fear conditioning. The effect of these treatments on hippocampus\u2010dependent memory was assessed using contextual fear\u2010conditioning tasks at day 4. To assess neocortex\u2010dependent memory, isoflurane anaesthesia or <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> was given 72\u2009h after contextual fear conditioning. Neocortex\u2010dependent memory assessment was performed at day 32.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Unlike <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> injection, isoflurane with buprenorphine\u2010induced anaesthesia does not impair freezing responses in hippocampus\u2010dependent fear\u2010conditioning memory tasks. On anterograde amnesia assessment: 49.67\u2009\u00b1\u20096.87% for the anaesthesia group and 54.5\u2009\u00b1\u20094.12% for the control group. On retrograde amnesia assessment: 47.16\u2009\u00b1\u20098.71% for the anaesthesia group and 54.5\u2009\u00b1\u20094.12% for control group; <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05. Thus, neither isoflurane nor buprenorphine impair hippocampus\u2010dependent memory. However, on the neocortex\u2010dependent memory task, both isoflurane\u2010induced anaesthesia and <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced inflammation result in reduced freezing responses: 62.13\u2009\u00b1\u20095.80% for the anaesthesia group, 74.63\u2009\u00b1\u20095.69% for the <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> group, and 81.75\u2009\u00b1\u20093.26% for the control group; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 compared with control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>General anaesthesia induced by isoflurane with buprenorphine may result in impairment of neocortex\u2010dependent memory in mouse. However, general anaesthesia so induced does not impair hippocampus\u2010dependent memory in mouse in our experimental conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02691.x","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T14:47:41Z","timestamp":1333550861000},"page":"1052-1057","source":"Crossref","is-referenced-by-count":14,"title":["Isoflurane causes neocortical but not hippocampal\u2010dependent memory impairment in mice"],"prefix":"10.1111","volume":"56","author":[{"given":"A. R.","family":"FIDALGO","sequence":"first","affiliation":[{"name":"Pain Medicine and Intensive Care Section, Department of Surgery and Cancer Chelsea and Westminster Hospital, Imperial College School of Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"CIBELLI","sequence":"additional","affiliation":[{"name":"Pain Medicine and Intensive Care Section, Department of Surgery and Cancer Chelsea and Westminster Hospital, Imperial College School of Medicine  London UK"},{"name":"Department of Cardiothoracic Anaesthesia Queen Elizabeth University Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P. M.","family":"WHITE","sequence":"additional","affiliation":[{"name":"Pain Medicine and Intensive Care Section, Department of Surgery and Cancer Chelsea and Westminster Hospital, Imperial College School of Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"NAGY","sequence":"additional","affiliation":[{"name":"Pain Medicine and Intensive Care Section, Department of Surgery and Cancer Chelsea and Westminster Hospital, Imperial College School of Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"WAN","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Gongli Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"MA","sequence":"additional","affiliation":[{"name":"Pain Medicine and Intensive Care Section, Department of Surgery and Cancer Chelsea and Westminster Hospital, Imperial College School of Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026394"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200205000-00027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200402000-00020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0b013e3182049f19"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21548"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200409000-00019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31819b62e2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.00057.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6896(03)00005-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02236.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.02098.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00043-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.07.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.04.063"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.073"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22082"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02585.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094804"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200402000-00019"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200106000-00021"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.09.022"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01823.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-04-01613.1998"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2012.02691.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2012.02691.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:06:09Z","timestamp":1695485169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2012.02691.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1399-6576.2012.02691.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2012.02691.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}