{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:49:18Z","timestamp":1776703758499,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:00:00Z","timestamp":1333497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Background<\/jats:title>The mortality of patients suffering from acute decompensated liver disease treated in the intensive care unit (ICU<\/jats:styled-content>) varies between 50% and 100%. Previously published data suggest that liver\u2010specific score systems are less accurate compared with the ICU<\/jats:styled-content>\u2010specific scoring systems acute physiology and chronic health evaluation II<\/jats:styled-content> (APACHE II<\/jats:styled-content>) and simplified organ failure assessment (SOFA<\/jats:styled-content>) in predicting outcome. We hypothesized that in a Scandinavian cohort of ICU<\/jats:styled-content> patients, APACHE II<\/jats:styled-content>, SOFA<\/jats:styled-content>, and simplified acute physiology score (SAPS II<\/jats:styled-content>) were superior to predict outcome compared with the C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh score.<\/jats:p><\/jats:sec>Methods<\/jats:title>A single\u2010centre retrospective cohort analysis was conducted in a university\u2010affiliated ICU<\/jats:styled-content>. Eighty\u2010seven adult patients with decompensated liver alcoholic cirrhosis were admitted from J<\/jats:styled-content>anuary 2007 to J<\/jats:styled-content>anuary 2010.<\/jats:p><\/jats:sec>Results<\/jats:title>The patients were severely ill with median scores: SAPS II<\/jats:styled-content> 60, SOFA<\/jats:styled-content> (day 1) 11, APACHE II<\/jats:styled-content> 31, and C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh 12. Receiver operating characteristic curves area under curve was 0.79 for APACHE II<\/jats:styled-content>, 0.83 for SAPS II<\/jats:styled-content>, and 0.79 for SOFA<\/jats:styled-content> (day1) compared with 0.59 for C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh. In patients only in need of mechanical ventilation, the 90\u2010day mortality was 76%. If respiratory failure was further complicated by shock treated with vasopressor agents, the 90\u2010day mortality increased to 89%. Ninety\u2010day mortality for patients in need of mechanical ventilation, vasoactive medication, and renal replacement therapy because of acute kidney injury was 93%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>APACHE II<\/jats:styled-content>, SAPS II<\/jats:styled-content>, and SOFA<\/jats:styled-content> were better at predicting mortality than the C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh score. With three or more organ failures, the ICU<\/jats:styled-content> mortality was >\u200990%. APACHE II<\/jats:styled-content> >\u200930, SAPS II<\/jats:styled-content> >\u200960, and SOFA<\/jats:styled-content> at day 1 >\u200912 were all associated with a mortality of >\u200990%. Referral criteria of patients suffering from decompensated alcoholic liver disease should be revised.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02692.x","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T14:48:34Z","timestamp":1333550914000},"page":"987-994","source":"Crossref","is-referenced-by-count":20,"title":["The outcome of critical illness in decompensated alcoholic liver cirrhosis"],"prefix":"10.1111","volume":"56","author":[{"given":"M.","family":"KAVLI","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Odense University Hospital, University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"STR\u00d8M","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Odense University Hospital, University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"CARLSSON","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Odense University Hospital, University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"DAHLER\u2010ERIKSEN","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Odense University Hospital, University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"TOFT","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine Odense University Hospital, University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2842-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02842.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26522"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1489"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050047"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2346-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)31377-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.2.9907034"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230615"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01772.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04341.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05908.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm744"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f3dea9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael177"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05269.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32834ab06f"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-6576.2012.02692.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-6576.2012.02692.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:06:10Z","timestamp":1695485170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-6576.2012.02692.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,4]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1399-6576.2012.02692.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-6576.2012.02692.x","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,4]]}}}