{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:11:17Z","timestamp":1790316677327,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative complications after open elective abdominal aortic surgery are common, and individualised goal\u2010directed therapy may improve outcome in high\u2010risk surgery. We hypothesised that individualised goal\u2010directed therapy, targeting stroke volume and oxygen delivery, can reduce complications and minimise length of stay in intensive care unit and hospital following open elective abdominal aortic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy patients scheduled for open elective abdominal aortic surgery were randomised to individualised goal\u2010directed therapy or conventional therapy. In the intervention group, stroke volume was optimised by 250\u2009ml colloid boluses intraoperatively and for the first 6\u2009h post\u2010operatively. The optimisation aimed at an oxygen delivery of 600\u2009ml\/min\/m<jats:sup>2<\/jats:sup> in the post\u2010operative period. Haemodynamic data were collected at pre\u2010defined time points, including baseline, intraoperatively and post\u2010operatively. Patients were followed up for 30 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stroke volume index and oxygen delivery index were both higher in the post\u2010operative period in the intervention group. In this group, 27 of 32 achieved the post\u2010operative oxygen delivery index target vs. 18 of 32 in the control group (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.01). However, the number of complications per patient or length of stay in the intensive care unit or hospital did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perioperative individualised goal\u2010directed therapy targeting stroke volume and oxygen delivery did not affect post\u2010operative complications, intensive care unit or hospital length of stay in open elective abdominal aortic surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1399-6576.2012.02756.x","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T11:03:16Z","timestamp":1345201396000},"page":"178-188","source":"Crossref","is-referenced-by-count":50,"title":["Optimising stroke volume and oxygen delivery in abdominal aortic surgery: a randomised controlled trial"],"prefix":"10.1111","volume":"57","author":[{"given":"J.","family":"BISGAARD","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Lillebaelt Hospital Kolding  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"GILSAA","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Lillebaelt Hospital Kolding  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"R\u00d8NHOLM","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Lillebaelt Hospital Kolding  Kolding Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"TOFT","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Odense University Hospital  Kolding 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