{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:48:12Z","timestamp":1760906892940},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T00:00:00Z","timestamp":1147046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Background and Objectives\u2002<\/jats:bold> Iatrogenic premature rupture of membranes (PROM) occurs in approximately 1% of patients after genetic amniocentesis. If membranes do not seal spontaneously, fluid leakage through the vagina may cause infection and pregnancy loss. Intra\u2010amniotic infusion of a platelet concentrate followed by a cryoprecipitate (amniopatch) is a possible therapeutic approach to restore the amnio\u2010corial link and to facilitate the amniotic repair process.<\/jats:p><jats:p><jats:bold>Materials and Methods\u2002<\/jats:bold> The autologeous platelet concentrate was produced by apheresis (MCS+, Haemonetics) and contained a total amount of 48\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup> platelets in a volume of 30\u00a0ml. The concentration of fibrinogen in our cryoprecipitate (20\u00a0ml) was 680\u00a0mg\/dl. An amniocentesis was performed to apply the amniopatch. The platelet concentrate was administered first followed by the cryoprecipitate.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We report the successful treatment of a 38\u2010year\u2010old woman with ruptured membranes after genetic amniocentesis in the 16th gestational week. Ten days after placement of the amniopatch we found a complete closure of the rupture, and in the 36th week of gestation the patient delivered a healthy infant by Caesarean section.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Intra\u2010amniotic injection of platelets and cryoprecipitate was a successful and safe therapy for PROM in this patient. Knowledge of the site of rupture is not necessary for the amniopatch, as platelets seem to find their way to the defect and seal it. We consider that amniopatch therapy for iatrogenic PROM is a possible therapeutic alternative for prolonging and preserving pregnancy and improving the fetal outcome.<\/jats:p>","DOI":"10.1111\/j.1423-0410.2006.00784.x","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T16:54:42Z","timestamp":1147107282000},"page":"88-90","source":"Crossref","is-referenced-by-count":17,"title":["Successful treatment of premature rupture of membranes after genetic amniocentesis by intra\u2010amniotic injection of platelets and cryoprecipitate (amniopatch): a case report"],"prefix":"10.1111","volume":"91","author":[{"given":"S.","family":"Sipurzynski\u2010Budra\u00df","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Macher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Haeusler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lanzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.09.003"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00050-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70522-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70252-2"},{"key":"e_1_2_5_6_2","first-page":"27","article-title":"Amniopatch, a repairing technique for premature rupture of amniotic membranes in second trimester","volume":"75","author":"Contino B","year":"2004","journal-title":"Acta Bio Med Ateneo Parmense"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(03)00083-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2600"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108872"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1423-0410.2006.00784.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1423-0410.2006.00784.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:57:33Z","timestamp":1696935453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1423-0410.2006.00784.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,8]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1423-0410.2006.00784.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1423-0410.2006.00784.x","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,8]]}}}