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Early buds are characterized by a branching morphogenesis of the ductal epithelium from which endocrine and exocrine precursor cells bud to eventually form the two other compartments. The three compartments are thought to be of common endodermal origin; in contrast to earlier hypotheses, which suggested that the endocrine compartment was of neuroectodermal origin. It is thus generally believed that the pancreatic endocrine\u2010lineage possesses the ability to mature along a differentiation pathway that shares many characteristics with those of neuronal differentiation. During recent years, studies of insulin\u2010gene regulation and, in particular, the tissue\u2010specific transcriptional control of insulin\u2010gene activity have provided information on pancreas development in general. The present review summarizes these findings, with a special focus on our own studies on pluripotent endocrine cultures of rat pancreas.<\/jats:p>","DOI":"10.1111\/j.1432-1033.1996.435rr.x","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T09:06:23Z","timestamp":1090573583000},"page":"435-445","source":"Crossref","is-referenced-by-count":42,"title":["Pancreatic Development and Maturation of the Islet B Cell"],"prefix":"10.1111","volume":"242","author":[{"given":"Ole Dragsb\u00e6k","family":"Madsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Blume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle V.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per B.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Inge","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Serup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,7,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/dev.122.5.1409","article-title":"The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1\/PDX1\u2010deficient mice","volume":"122","author":"Ahlgren U.","year":"1996","journal-title":"Development (Camb.)"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002010107"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90391-1"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.2.S546"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.14.3893"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1210865"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.19.6450"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.6.2.299"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118278"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.10.883"},{"key":"e_1_2_2_12_1","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2337\/diab.42.12.1715","article-title":"A 2nd for regeneration of adult exocrine and endocrine pancreas \u2013 a possible recapitulation of embryonic\u2010development","volume":"42","author":"Bonner\u2010Weir S.","year":"1993","journal-title":"Diabetes"},{"key":"e_1_2_2_13_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02912833","article-title":"Immunofluorescence, histochemical and ultrastructural studies for the detection of multiple endocrine polypeptide tumours of the pancreas","volume":"17","author":"Bordi C.","year":"1974","journal-title":"Virchows Arch. 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