{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:48:57Z","timestamp":1758635337589},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The distributions and frequencies of some endocrine cells in the eight portions of the gastrointestinal (GI) tract \u2013 fundus, pylorus, duodenum, jejunum, ileum, cecum, colon and rectum of the nude mouse, Balb\/c\u2010nu\/nu were studied with immunohistochemical method using six types of anti\u2010sera against serotonin, gastrin, cholecystokinin (CCK)\u20108, somatostatin, glucagon and human pancreatic polypeptide (hPP). All of six types of immunoreactive (IR) cells were identified. Most of IR cells in the intestinal portion were generally spherical or spindle in shape (open type cell) while cells showing round in shape (close type cell) were found in the intestinal gland and stomach regions occasionally. Their relative frequencies were varied according to each portion of GI tract. Serotonin\u2010IR cells were detected throughout the whole GI tract and they showed the highest frequency in the pylorus. Gastrin\u2010IR cells were restricted to the pylorus and duodenum with numerous and a few frequencies, respectively. CCK\u20108\u2010IR cells were also restricted to the pylorus, duodenum and jejunum with numerous, a few and rare frequencies, respectively. Somatostatin\u2010IR cells were demonstrated throughout the whole GI tract except for the colon and rectum, and they showed the highest frequency in the fundus. In addition, glucagon\u2010 and hPP\u2010IR cells were restricted to the fundus and rectum, respectively with a few frequencies. In conclusion, the general distribution patterns and relative frequency of GI endocrine cells of the nude mouse, Balb\/c\u2010nu\/nu was similar to that of other strains of mice. However, some strain and\/or species\u2010dependent unique distributions and frequencies of endocrine cells were also observed especially for somatostatin\u2010 and hPP\u2010IR cells.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2005.00645.x","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T11:42:59Z","timestamp":1129722179000},"page":"104-110","source":"Crossref","is-referenced-by-count":8,"title":["The Regional Distribution and Relative Frequency of Gastrointestinal Endocrine cells in the Nude Mice, Balb\/c\u2010nu\/nu: An Immunohistochemical Study"],"prefix":"10.1111","volume":"35","author":[{"given":"S. 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