{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:25:59Z","timestamp":1780403159850,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,31]],"date-time":"2007-01-31T00:00:00Z","timestamp":1170201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The immunohistolocalization of secretory carbonic anhydrase isoenzymes (CA\u2010VI) in canine salivary glands, parotid, submandibular, sublingual and zygomatic glands, oral and oesophageal mucosa was studied using a specific antiserum against a canine CA\u2010VI. In addition, the gene expression of CA\u2010VI from the same tissue was studied using a real\u2010time reverse\u2010transcriptase polymerase chain reaction. In all salivary glands and oesophageal gland, immunostaining intensely localized CA\u2010VI antiserum throughout the cytoplasm of serous acinar cells, including serous demilune and ductal epithelial cells. In contrast, no immunoreaction localized CA\u2010VI in the mucous acinar cells of the gland. CA\u2010VI gene transcripts were also detected in the same areas. The physiological significance of secretory CA\u2010VI in the oral and oesophageal cavity is thought to play a highly specialized role in the maintenance of bicarbonate level in saliva and to protect mucosa from acid injury. It is shown that the major sites of the CA\u2010VI secretion in dogs were in serous (demilune) secretory cells in all four major salivary glands and oesophageal glands in particular.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2006.00721.x","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T21:19:19Z","timestamp":1170451159000},"page":"53-57","source":"Crossref","is-referenced-by-count":11,"title":["Immunohistolocalization and Gene Expression of the Secretory Carbonic Anhydrase Isozymes (CA\u2010VI) in Canine Oral Mucosa, Salivary Glands and Oesophagus"],"prefix":"10.1111","volume":"36","author":[{"given":"T.","family":"Kasuya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ichihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Asari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0264.2000.00234.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016762"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(83)96020-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)91031-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(79)80634-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2590091"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5938"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199912000-00005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199912000-00006"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpev.1996.0006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.1167"},{"key":"e_1_2_5_13_1","first-page":"99","article-title":"Isolation of a novel carbonic anhydrase from human saliva and immunohistochemical demonstration of its related isozymes in salivary gland","volume":"33","author":"Kadoya Y. T.","year":"1987","journal-title":"Osaka City Med. J."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.t01-1-00315.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900513"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6282.2004"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75797-4"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042517031000112633"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/40.6.1588027"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/41.3.8429198"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000608"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(75)90434-0"},{"key":"e_1_2_5_23_1","first-page":"1","volume-title":"Handbook of Experimental Immunology","author":"Ouchterlony O.","year":"1978"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/38.7.2113069"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018889120034"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050128"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950100603"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)60323-5"}],"container-title":["Anatomia, Histologia, Embryologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0264.2006.00721.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0264.2006.00721.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0264.2006.00721.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:21:32Z","timestamp":1694719292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0264.2006.00721.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,31]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1439-0264.2006.00721.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0264.2006.00721.x","archive":["Portico"],"relation":{},"ISSN":["0340-2096","1439-0264"],"issn-type":[{"value":"0340-2096","type":"print"},{"value":"1439-0264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,31]]}}}