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The objective of the present study was to characterize the expression of insulin\u2010like growth factor (IGF)\u2010I, fibroblast growth factor (FGF)\u20102 and vascular endothelial growth factor (VEGF) in induced COD using immunohistochemistry. We used an experimental model based on the exposure to constant light of adult rats during 15\u2003weeks. We quantified the expression of GFs in cystic and normal ovaries by the Immunohistochemical Stained Area (IHCSA). In animals with COD, a significant reduction in the IHCSA of IGF\u2010I in the follicular fluid, theca and granulosa layers of cysts occurred; and an increase in the interstitial tissue with regard to the control group. We found moderate immunoreactivity of FGF\u20102 in granulosa and theca layers of secondary and tertiary follicles and lower expression in the granulosa and theca interna layers of cystic follicles. Immunoexpression of VEGF was found in granulosa and theca cells of secondary and tertiary follicles. This study shows changes in the ovarian expression of IGF\u2010I, FGF\u20102 and VEGF in induced COD. We can propose that an alteration in the control of the follicular dynamic, through the GFs, added to other features, could be involved in the ovarian cyst pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2006.00726.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:50:20Z","timestamp":1166687420000},"page":"94-102","source":"Crossref","is-referenced-by-count":18,"title":["Intraovarian Localization of Growth Factors in Induced Cystic Ovaries in Rats"],"prefix":"10.1111","volume":"36","author":[{"given":"H. H.","family":"Ortega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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