{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:33:42Z","timestamp":1759581222967},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pterygial pathology is characterized by abnormal corneal epithelial proliferation, stromal modulation, matrix degradation and a strong tendency for otherwise absent corneal vascularization. As the proto\u2010oncogene Ets\u20101 is known to play a key role in angiogenesis and matrix degradation in other tissues, its involvement in corneal vascularization was investigated. Fifteen pterygia representing two groups were studied. Group 1 consisted of five clinically active pterygia, and group 2 consisted of 10 samples of clinically non\u2010active pterygia. <jats:sup>35<\/jats:sup>S\u2010labelled <jats:italic>ets\u20101<\/jats:italic> antisense and sense riboprobes were used for <jats:italic>in\u2010situ<\/jats:italic> hybridization of Ets\u20101 transcription factor in all pterygia. The cytoplasm of blood vessel endothelial cells showed strong expression of <jats:italic>ets\u20101<\/jats:italic> mRNA in all group 1 pterygia. In contrast, no expression of <jats:italic>ets\u20101<\/jats:italic> was found in group 2 pterygia. Proto\u2010oncogene <jats:italic>ets\u20101<\/jats:italic> expression has been shown for the first time in the metaplastic pterygium, an eye tissue of unknown pathogenesis.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2006.00730.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T07:50:20Z","timestamp":1166687420000},"page":"107-110","source":"Crossref","is-referenced-by-count":7,"title":["The Ets\u20101 Transcription Factor is Involved in Pterygial Angiogenesis"],"prefix":"10.1111","volume":"36","author":[{"given":"W.","family":"Naib\u2010Majani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Breipohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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