{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:54:17Z","timestamp":1696913657268},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T00:00:00Z","timestamp":1178236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat Histol Embryol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The presence and co\u2010localization of vasoactive intestinal polypeptide (VIP), peptide N\u2010terminal histidine C\u2010terminal isoleucine (PHI), pituitary adenylate cyclase\u2010activating peptide (PACAP), somatostatin (SOM), calcitonin gene\u2010related peptide (CGRP), substance P (SP) and the neuronal isoform of nitric oxide synthase (NOS) were studied in neuronal structures of the pig pineal gland. Paraformaldehyde\u2010fixed pineals of 3\u2010month\u2010old gilts were sliced into serial cryostat sections, which were subjected to a set of double immunofluorescence stainings. Based on the co\u2010existence patterns of neuropeptides, five populations of nerve fibres supplying the pig pineal were distinguished: (1) PHI\u2010positive, (2) PACAP\u2010positive, (3) SOM\u2010positive, (4) SP\/CGRP\u2010positive and (5) SP\u2010positive\/CGRP\u2010negative. Only a subpopulation of PHI\u2010positive fibres contained VIP at the level detectable by immunofluorescence. NOS was found in some intrapineal PHI\u2010 and VIP\u2010positive fibres. PHI\u2010, VIP\u2010 and NOS\u2010positive nerve fibres were more numerous in the peripheral than in the central part of the pineal. PACAP\u2010positive fibres were equally distributed within the gland. The density of SOM\u2010positive fibres was higher in the ventro\u2010proximal than in the dorso\u2010distal part of the pineal. SOM was also detected in some neuronal\u2010like cells or specialized pinealocytes situated in the central region of the gland. Two populations of fibres containing SP were found: CGRP\u2010positive, present in the distal and central parts of the pineal as well as CGRP\u2010negative, localized in the proximal compartment of the gland.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2007.00767.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T07:17:47Z","timestamp":1178695067000},"page":"311-320","source":"Crossref","is-referenced-by-count":3,"title":["Peptidergic and Nitrergic Innervation of the Pineal Gland in the Domestic Pig: An Immunohistochemical Study"],"prefix":"10.1111","volume":"36","author":[{"given":"M.","family":"Nowicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wojtkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lewczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kosacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Przybylska\u2010Gornowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00183.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66020748.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01856-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1994.tb00109.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489552"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"111","article-title":"Pre\u2010synaptic autoregulation of norepinephrine release from the sympathetic nerve fibres in the pineal gland of the domestic pig. 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