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A morphometric study was carried out on rabbit tibiae comparing size increments and shape changes in relation to age. Utilizing measurements made using dried bones, radiography and computerized tomography, it was possible to perform a three\u2010dimensional analysis of shape modulation occurring during a period of growth extending from 3\u00a0months to 1\u00a0year of age. The dynamics of the shape changes related to growth were studied with a fluorescent tetracycline labelling. This enabled correlation of shape modulation with the 3\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> distribution of apposition and resorption. The current thinking behind the influences and mechanical forces affecting bone architecture was discussed in the light of these findings. Several factors play a role in the structural organization of the human and upper vertebrates\u2019 skeleton, whose shape is genetically determined in the complex process usually referred as \u2018modelling\u2019. This does not conflict with the existing evidence of remodelling being influenced by mechanical stimuli, but the unsolved question remains how physical forces (strains) act on the biological substrate of cartilage and bone cells.<\/jats:p>","DOI":"10.1111\/j.1439-0264.2011.01126.x","type":"journal-article","created":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T05:49:28Z","timestamp":1325569768000},"page":"217-226","source":"Crossref","is-referenced-by-count":2,"title":["Growth and Shape Modelling of the Rabbit Tibia"],"prefix":"10.1111","volume":"41","author":[{"given":"U. 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