{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:30:07Z","timestamp":1792632607472,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1111\/j.1439-0272.2011.01191.x","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T03:33:20Z","timestamp":1310960000000},"page":"370-375","source":"Crossref","is-referenced-by-count":16,"special_numbering":"supplement s1","title":["Effects of chronic tadalafil use on the testes and sperm parameters of old albino rats"],"prefix":"10.1155","volume":"44","author":[{"given":"M. A. M.","family":"Khalaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"El-Fakahany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/mrd.20265","article-title":"Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation","volume":"71","author":"Baxendale","year":"2005","journal-title":"Mol Reprod Dev"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB2|cit2","first-page":"1395","article-title":"Phosphodiesterase type 11 (PDE11) cellular localization: progress towards defining a physiological role in testis and\/or reproduction","volume":"165","author":"Baxendale","year":"2001","journal-title":"J Urol Suppl"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB3|cit3","volume-title":"Cialis (Tadalafil) label insert","author":"Eli Lilly and Icos Company","year":"2005"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0090-4295(01)00984-0","article-title":"Efficacy, safety, and use of sildenafil in urologic practice","volume":"57","author":"Fagelman","year":"2001","journal-title":"J Urol"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB5|cit5","first-page":"273","article-title":"The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension","volume":"6","author":"Falk","year":"2010","journal-title":"Vasc Health Risk Manag"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1073\/pnas.050585197","article-title":"Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A","volume":"97","author":"Fawcett","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB7|cit7","volume-title":"Sponsored by World Health Organization (WHO), International Consultation on Urological Disease (ICUD), and Soci\u00e9t\u00e9 Internationale d\u2019Urologie (SIU)","author":"First International Consultation on Erectile Dysfunction","year":"1999"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB8|cit8","article-title":"Expression of phosphodiesterase type 5A in human spermatozoa and influence of its inhibition on motility and functional sperm parameters","author":"Foresta","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.ijir.3901377","article-title":"Phosphodiesterase 11 (PDE11): is it a player in human testicular function?","volume":"17","author":"Francis","year":"2005","journal-title":"Int J Impot Res"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/01.ju.0000081053.97792.da","article-title":"Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones","volume":"170","author":"Hellstrom","year":"2003","journal-title":"J Urol"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.eururo.2007.09.046","article-title":"An evaluation of semen characteristics in men 45\u2003years of age or older after daily dosing with tadalafil 20\u2003mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study","volume":"53","author":"Hellstrom","year":"2008","journal-title":"Eur Urol"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB12|cit12","first-page":"176","article-title":"Erectile disorders: the realty","volume":"40","author":"Hengeveld","year":"2001","journal-title":"Eur Urol"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1124\/jpet.110.170191","article-title":"Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect","volume":"334","author":"Koka","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB14|cit14","first-page":"276","article-title":"Therapeutic effect of phosphodiesterase-5 inhibitor on pathological changes of tunica albuginea in erectile dysfunction: experiment with rats","volume":"89","author":"Ma","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/sj.ijir.3901441","article-title":"Phosphodiesterase 11: a brief review of structure, expression and function","volume":"18","author":"Makhlouf","year":"2006","journal-title":"Int J Impot Res"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1743-6109.04042.x","article-title":"Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil","volume":"1","author":"McMahon","year":"2004","journal-title":"J Sex Med"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1439-0272.2006.00752.x","article-title":"Tadalafil as an in vitro sperm motility stimulant","volume":"39","author":"Mostafa","year":"2007","journal-title":"Andrologia"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0090-4295(03)00567-3","article-title":"Minimal time to successful intercourse after sildenafil citrate: results of a randomized, double-blind, placebo-controlled trial","volume":"62","author":"Padma-Nathan","year":"2003","journal-title":"Urology"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB19|cit19","first-page":"332","volume-title":"Pharmacometrics","author":"Paget","year":"1964"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.fertnstert.2006.12.019","article-title":"Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men","volume":"88","author":"Pomara","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB21|cit21","first-page":"S20","article-title":"Tadalafil has no effect on testes in rodents","volume":"14","author":"Sausen","year":"2002","journal-title":"Int J Impot Res"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.ijir.3901491","article-title":"The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems","volume":"19","author":"Schwarz","year":"2007","journal-title":"Int J Impot Res"},{"key":"10.1111\/j.1439-0272.2011.01191.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/sj.ijir.3901307","article-title":"Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology","volume":"17","author":"Wayman","year":"2005","journal-title":"Int J Impot Res"}],"container-title":["Andrologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0272.2011.01191.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1439-0272.2011.01191.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:33:44Z","timestamp":1671521624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0272.2011.01191.x"}},"subtitle":["Chronic tadalafil effect on fertility"],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":23,"URL":"https:\/\/doi.org\/10.1111\/j.1439-0272.2011.01191.x","relation":{},"ISSN":["0303-4569"],"issn-type":[{"value":"0303-4569","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}