{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:11:43Z","timestamp":1768903903840,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Naringenin is a bioactive flavanone involved in the inhibition of drug metabolism which exhibits antioxidant, anti\u2010inflammatory and anticancerogenic properties and which recently appeared to be a factor mitigating the hyperlipidaemic effects in rats and rabbits. In the performed experiment, the effect of naringenin, administered intragastrically (50\u2003mg\/kg) for 2\u2003weeks to normal and ethanol drinking rats, on insulin and leptin levels and on some metabolic parameters was investigated. Naringenin did not change the hormone levels in any group of rats. Blood glucose, triglyceride, total, esterified and free cholesterol and high\u2010density lipoprotein\u2010cholesterol concentrations were also unaffected by this compound. Only free fatty acids were elevated after the naringenin treatment in the water\u2010drinking rats. In spite of unchanged glucose and insulin concentrations in blood, the tested flavanone reduced the glucose\/insulin ratio in ethanol\u2010receiving rats. Liver triglycerides, elevated due to ethanol ingestion, were partially normalized by naringenin. Other tested parameters like liver glycogen and cholesterol, muscle triglycerides and glycogen were not altered in any group of rats. The influence of naringenin (62.5, 125, 250 and 500\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>) on basal and insulin\u2010stimulated glucose conversion to lipids (lipogenesis) as well as on basal and epinephrine\u2010stimulated glycerol release (lipolysis) in the isolated rat adipocytes was also tested. The basal and the stimulated lipogenesis tended to be decreased in the presence of the flavanone (250\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>). This inhibitory effect intensified and was statistically significant at the highest concentration of naringenin. The tested compound did not evoke any effect on basal lipolysis while the epinephrine\u2010stimulated process was limited at the highest concentration of the flavanone. Naringenin (62.5, 125, 250 and 500\u2003<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>) had no effect on leptin secretion from the isolated rat adipocytes. Results obtained in our studies demonstrate that naringenin exerts a very weak influence on carbohydrate and lipid metabolism of normal and ethanol\u2010consuming rats and on metabolism of isolated rat adipocytes.<\/jats:p>","DOI":"10.1111\/j.1439-0396.2006.00647.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T08:30:16Z","timestamp":1162888216000},"page":"91-99","source":"Crossref","is-referenced-by-count":15,"title":["In vivo metabolic effects of naringenin in the ethanol consuming rat and the effect of naringenin on adipocytes in vitro"],"prefix":"10.1111","volume":"91","author":[{"given":"K.","family":"Szkudelska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nogowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Nowicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Szkudelski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01517-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90164-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-999-0403-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2004.pto_940106.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.126.2.524"},{"key":"e_1_2_5_7_1","first-page":"67","article-title":"Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids","volume":"41","author":"Buening M. 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