{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:35:52Z","timestamp":1793450152321,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T00:00:00Z","timestamp":1169078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study was conducted to investigate the effect of vitamin A and E supplementation on the antioxidant defences of broiler chickens against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced oxidative stress at 4\u2003weeks of age. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities as well as total antioxidant (TAO) level were analysed before and after CCl<jats:sub>4<\/jats:sub> challenge. Day\u2010old Lohman broiler chickens (<jats:italic>n<\/jats:italic>\u2003=\u2003144) were randomly assigned to six factorially arranged dietary treatments consisting of vitamin A [1.35 (control) or +20\u2003mg\/kg] and vitamin E [20 (control), +40 or +60\u2003mg\/kg]. The background of vitamins A and E in the basal diet was 4500\u2003IU (1.35\u2003mg) and 30\u2003IU (20\u2003mg) respectively. At 4\u2003weeks of age, eight chickens from each treatment were bled before interperitoneal injection with 1\u2003ml of CCl<jats:sub>4<\/jats:sub> (mixed with olive oil in a ratio of 1:1) and bled again 24\u2003h post\u2010injection. Vitamin E supplementation decreased (p\u2003&lt;\u20030.05) the activity of both SOD and GPX and showed a tendency (p\u2003=\u20030.07) for TAO reduction. CCl<jats:sub>4<\/jats:sub> attenuated SOD and GPX activities as well as TAO level. The decrease was profound (p\u2003&lt;\u20030.05) in chickens fed the basal diet as well as those fed basal diet supplemented with 20\u2003mg vitamin A. TAO levels behaved similarly when chickens were challenged with CCl<jats:sub>4<\/jats:sub>. After CCl<jats:sub>4<\/jats:sub> injection, SOD activities of all experimental groups were equivalent. The presence of vitamin A decreased (p\u2003&lt;\u20030.05) plasma GPX activity in chickens fed the basal diet supplemented with 40\u2003mg\/kg of vitamin E. Results of this experiment suggested that vitamin E supplementation elevated antioxidant enzyme activities while vitamin A supplementation attenuated this effect. Vitamin E supplementation improved the total reducing power by maintaining comparable levels of TAO upon CCl<jats:sub>4<\/jats:sub> challenge. Further experiments need to be carried out to investigate the role of vitamin A in oxidative stress and to evaluate the lipid peroxidation products.<\/jats:p>","DOI":"10.1111\/j.1439-0396.2006.00659.x","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T03:11:19Z","timestamp":1169176279000},"page":"333-340","source":"Crossref","is-referenced-by-count":14,"title":["Effect of vitamin A and\/or E on plasma enzymatic antioxidant systems and total antioxidant capacity of broiler chickens challenged with carbon tetrachloride"],"prefix":"10.1111","volume":"91","author":[{"given":"K. Z.","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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