{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T02:17:55Z","timestamp":1766888275151},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nine non\u2010pregnant, lactating dairy cows were used to study plasma and urinary magnesium concentrations ([Mg]<jats:sub>pl<\/jats:sub>; [Mg]<jats:sub>u<\/jats:sub>), and the urinary fractional excretion of magnesium (FE<jats:sub>Mg<\/jats:sub>) before, during and after an 120\u2003min intravenous magnesium (Mg) administration (2.5\u2003mg\/kg body weight). Animals received a total mixed ration, and Mg content of the diet was within recommended range. Basal mean [Mg]<jats:sub>pl<\/jats:sub>, [Mg]<jats:sub>u<\/jats:sub>and FE<jats:sub>Mg<\/jats:sub>were 0.89\u2003\u00b1\u20030.09\u2003m<jats:sc>m<\/jats:sc>, 5.92\u2003\u00b1\u20032.99\u2003m<jats:sc>m<\/jats:sc>and 8.3\u2003\u00b1\u20039.7% respectively. For all parameters, a substantial inter\u2010individual variation was observed. Three cows showed suboptimal [Mg]<jats:sub>pl<\/jats:sub>and\/or [Mg]<jats:sub>u<\/jats:sub>as well as low FE<jats:sub>Mg<\/jats:sub>values of approximately 2% indicating an insufficient Mg supply to these animals (depressed feed intake, reduced absorption of Mg). The applied Mg challenge induced no significant change of mean [Mg]<jats:sub>pl<\/jats:sub>in the cows because part of the excess Mg was excreted in the urine. But in five out of nine cows, a decrease of the FE<jats:sub>Mg<\/jats:sub>, during and after an intravenous Mg load was observed showing that part of the infused Mg is used to replenish intracellular Mg pools. Thus, the existence of an intracellular Mg deficiency in these cows was unmasked by performing the Mg loading test only. Because a reduced free intracellular [Mg] impairs cell and tissue functions, the results highlight the importance of an accurate definition of the intracellular Mg status. The Mg loading test is a suitable procedure, however, for practical purposes less expensive and time consuming methods must be developed.<\/jats:p>","DOI":"10.1111\/j.1439-0396.2007.00787.x","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T12:05:36Z","timestamp":1205409936000},"page":"105-112","source":"Crossref","is-referenced-by-count":7,"title":["Indication of intracellular magnesium deficiency in lactating dairy cows revealed by magnesium loading and renal fractional excretion"],"prefix":"10.1111","volume":"93","author":[{"given":"M.","family":"Schweigel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mohr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,7]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Empfehlungen zur Energie und N\u00e4hrstoffversorgung der Milchk\u00fche und Aufzuchtrinder","author":"Ausschuss f\u00fcr Bedarfsnormen der Gesellschaft f\u00fcr Ern\u00e4hrungsphysiologie","year":"2001"},{"key":"e_1_2_6_3_1","first-page":"11","article-title":"Magnesium regulation of Ca2+channels in smooth muscle and endothelial cells of human allantochorial placental vessels","volume":"14","author":"Bara M.","year":"2001","journal-title":"Magnesium Research"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84628-483-0_17"},{"key":"e_1_2_6_5_1","first-page":"118","volume-title":"Veterin\u00e4rmedizinische Laboruntersuchungen f\u00fcr die Diagnose und Verlaufskontrolle","author":"Baumgartner W.","year":"1985"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1989.sp003275"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32351-8"},{"key":"e_1_2_6_8_1","first-page":"225","article-title":"Structural and catalytic chemistry of magnesium\u2010dependent enzymes","volume":"15","author":"Cowan J. 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