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Forty female outbred Wistar Han rats, sham\u2010operated (SHAM, positive control, <jats:italic>n<\/jats:italic>\u2003=\u200310) or ovariectomized (OVX, <jats:italic>n<\/jats:italic>\u2003=\u200330) at 4\u2003months of age, were allotted into following groups (<jats:italic>n<\/jats:italic>\u2003=\u200310\/group): (i) SHAM, (ii) OVX control (negative control), (iii) OVX\u2003+\u2003LaCO<jats:sub>3<\/jats:sub> (1.74\u2003g\/kg feed) and (iv) OVX\u2003+\u2003Lancer<jats:sup>\u00ae<\/jats:sup> (8\u2003g\/kg feed). Effects on bone were investigated by bone markers [osteocalcin (Oc) in serum and excretion of pyridinoline (PYD) in urine] and by physical parameters of bone structure and bone composition (bone mass, calcium, phosphorus and magnesium content in bone crude ash). Bone micro\u2010architecture and bone mineral density were evaluated by peripheral quantitative computed tomography and micro\u2010computed tomography (\u03bcCT). The animal model could be validated by differences between OVX control and SHAM. Body mass and feed intake were the same among the four groups. Oc was clearly increased in the two experimental groups (p\u2003&lt;\u20030.001) vs. SHAM and OVX control. Bone mass and calcium content in bone ash were significantly higher than in OVX control. The Ca\/P ratio in bone ash of the two lanthanide groups did not differ from SHAM. Bone\u2010protecting effects of lanthanides were clearly demonstrated by an increased trabecular density which is the region of interest for osteoporotic bone loss. A 3D imaging of bone micro\u2010architecture by \u03bcCT visualized descriptively the positive effects of lanthanides on bone formation. The results of this study demonstrate an improvement of bone formation and bone\u2010protecting effects of lanthanides in the OVX rat. Thus, lanthanum salts suggest a prevention of post\u2010menopausal bone loss and may be of benefit in experimental osteopenia following ovariectomy.<\/jats:p>","DOI":"10.1111\/j.1439-0396.2012.01326.x","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T05:00:27Z","timestamp":1343624427000},"page":"885-894","source":"Crossref","is-referenced-by-count":21,"title":["Lanthanum salts improve bone formation in a small animal model of post\u2010menopausal osteoporosis"],"prefix":"10.1111","volume":"96","author":[{"given":"S. J.","family":"von Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. 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