{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:47:51Z","timestamp":1788587271871,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In order to test the hypothesis that ruminal drinking in calves can lead to\n                    <jats:sc>d<\/jats:sc>\n                    \u2010lactic metabolic acidosis, ruminal acidosis was induced in nine calves by intraruminal application of untreated whole milk via a stomach tube. The amount of the daily force\u2010fed liquid was 3\u2003\u00d7\u20031\u2003l. The experimental design called for an end of intraruminal applications if two or more of the following signs were observed: severe depression, estimated degree of dehydration &gt;10%, absence of sucking reflex, lack of appetite for two consecutive feedings, severe metabolic acidosis with calculated Actual Base Excess (ABE) &lt;\u221215\u2003mmol\/l. The procedure was scheduled to be discontinued on the 17th day of experiment. The onset of ruminal acidification occurred rapidly, and mean pH value fell from 6.70 (\u00b10.48) to 4.90 (\u00b10.38) after the first application. The following days the pH values varied between 4 and 5. Rumen acidity was characterized biochemically by a significant increase in both isomers of lactic acid. The effects of the intraruminal administration on the calves were detrimental; eight of nine calves showed an acute disease process. According to the pre\u2010established clinical standard, seven of nine calves were removed from the intraruminal feeding schedule. All but one of the calves developed severe systemic acidosis. The increase in anion gap demonstrated the net acid load. In all the calves\n                    <jats:sc>d<\/jats:sc>\n                    \u2010lactate levels were found to show a significant and rapid increase. On the contrary,\n                    <jats:sc>l<\/jats:sc>\n                    \u2010lactate never deviated from physiological levels. These observations confirm that, in young calves as in adult cattle, ruminal acidosis may lead to a clinically manifested\n                    <jats:sc>d<\/jats:sc>\n                    \u2010lactic metabolic acidosis.\n                  <\/jats:p>","DOI":"10.1111\/j.1439-0442.2004.00600.x","type":"journal-article","created":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T09:54:58Z","timestamp":1085046898000},"page":"64-70","source":"Crossref","is-referenced-by-count":51,"title":["<scp>d<\/scp>\n                    \u2010Lactic Acidosis in Calves as a Consequence of Experimentally Induced Ruminal Acidosis"],"prefix":"10.1111","volume":"51","author":[{"given":"A.","family":"Gentile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sconza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Otranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rademacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Famigli\u2010Bergamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Klee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_21_2_1","first-page":"559","article-title":"The colon, the rumen, and d\u2010lactic acidosis (Editorial)","volume":"336","author":"Anonymous","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_21_3_1","unstructured":"Baur T. 1993:Untersuchungen \u00fcber den Einflu\u00df der intraruminalen Verabreichung von Milch beim jungen Kalb.Vet. Med. Diss. M\u00fcnchen Germany."},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1150055"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110216"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60774-5"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60764-2"},{"key":"e_1_2_21_8_1","first-page":"259","article-title":"Valutazione dei parametri dell'immunit\u00e0 innata, non\u2010specifica, in vitelli con acidosi ruminale","volume":"50","author":"Dall'Ara P.","year":"1996","journal-title":"Atti. Soc. It. Sci. Vet."},{"key":"e_1_2_21_9_1","first-page":"259","article-title":"Pathogenesis of ruminant lactic acidosis","volume":"16","author":"Dunlop R. H.","year":"1972","journal-title":"Adv. Vet. Sci. Comp. 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Proceedings of the 10th Magyar Buiatrikus Kongresszus K\u00f6z\u00e8p\u2010Eur\u00f3pai Buiatrikus Tal\u00e1lkoz\u00f3 Middle European Buiatrics Congress 21\u201323\/05\/1998 Si\u00f3fok Ungheria 47\u201351."},{"key":"e_1_2_21_14_1","first-page":"293","article-title":"Acidosi ruminale cronica nel vitello lattante indotta da somministrazione intraruminale di latte ricostituito","volume":"28","author":"Gentile A.","year":"1996","journal-title":"Atti. Soc. It. Buiatria"},{"key":"e_1_2_21_15_1","first-page":"205","article-title":"Systemische Auswirkungen der Pansenazidose im Gefolge von Pansentrinken beim Milchkalb","volume":"26","author":"Gentile A.","year":"1998","journal-title":"Tier\u00e4rztl Prax."},{"key":"e_1_2_21_16_1","doi-asserted-by":"crossref","unstructured":"Grude T. I.Lorenz G.Rademacher A.Gentile andW.Klee 1999:Levels of d\u2010 and L\u2010lactate in rumen liquid blood and urine in calves with and without evidence of ruminal drinking. Proceedings 32nd Annual Convention AABP 23\u201326\/09\/1999 Nashville Tennessee (USA) 213\u2013214.","DOI":"10.21423\/aabppro19995543"},{"key":"e_1_2_21_17_1","first-page":"157","article-title":"d\u2010Lactic acidosis in short bowel syndrome \u2013 an examination of possible mechanisms","volume":"74","author":"Hudson M.","year":"1990","journal-title":"Q. J. Med."},{"key":"e_1_2_21_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1058715"},{"key":"e_1_2_21_19_1","unstructured":"Lorenz I. 2002:Influence of serum d\u2010lactate concentration on clinical signs in calves with metabolic acidosis. Congress Abstracts of the 22nd World Buiatrics Congress 18\u201323\/08\/2002 Hannover (Germany) Abstract no. 542\u2013326 (CD\u2010rom)."},{"key":"e_1_2_21_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-003-0499-6"},{"key":"e_1_2_21_21_1","unstructured":"Naylor J. M. J. B.Ewaschuk G. 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