{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:44:41Z","timestamp":1788601481194,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T00:00:00Z","timestamp":1085011200000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to evaluate the therapeutic efficacy of commonly used acaricidal drugs in India and also to assess the effect of ascorbic acid (AA) as adjunct therapy in 72 growing sheep with sarcoptic mange, aged 5\u20136\u2003months and weighing 20.4\u201331.7\u2003kg. Eight replicates of nine animals were formed based on sex, and day 0 body weight. Another set of 12 healthy sheep (5\u20136\u2003months old) constituted the healthy control group. Drugs were applied locally on the affected parts daily and recovery changes in skin lesions were observed at the time of every application. <jats:sc>l<\/jats:sc>\u2010Ascorbic acid was administered intramuscularly. Skin scrapings were collected daily from each group and examined for the presence of mites. Blood samples from each group were collected and analysed for total erythrocytes, leucocytes, haematocrit, haemoglobin and lymphocytes on 0, 14th and 28th day post\u2010treatment (PT). Cell\u2010mediated (CMI) and humoral immune (HI) responses were assessed on 0 and 28\u2003days PT. Within groups treated with the drug alone, recovery in oil of <jats:italic>Jatropha curcas<\/jats:italic> group was faster and lesions were free from mites after the eighth application. For each drug, the recovery was faster with AA as an adjunct therapy when compared with the group treated with the drug alone. Within all groups, recovery in oil of <jats:italic>J. curcas<\/jats:italic> plus ascorbic acid (OJC\u2010AA) group was fastest and the lesions were mite\u2010free after three applications. The overall mean values were higher for all haematological parameters in OJC\u2010AA group. Recovery with respect to suppressed CMI and HI responses during infection was also faster in this group. Gross and microscopic pathological studies revealed a marked adverse effect of infection on skin, kidney, spleen and liver. The OJC\u2010AA group indicated faster recovery. It is concluded from this study that oil of <jats:italic>J. curcas<\/jats:italic> was found more efficacious in controlling sarcoptic mange in sheep and AA might be beneficial as adjunct in case of sarcoptic mange to get quick recovery with lesser applications of main therapy. However, the pharmacology of AA with reference to health of skin needs to be investigated.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2004.00601.x","type":"journal-article","created":{"date-parts":[[2004,5,20]],"date-time":"2004-05-20T13:54:58Z","timestamp":1085061298000},"page":"71-78","source":"Crossref","is-referenced-by-count":16,"title":["Effects of Sarcoptic Mange and its Control with Oil of <i>Cedrus deodara<\/i>, <i>Pongamia glabra<\/i>, <i>Jatropha curcas<\/i> and Benzyl Benzoate, both with and without Ascorbic Acid on Growing Sheep: Epidemiology; Assessment of Clinical, Haematological, Cell\u2010Mediated Humoral Immune Responses and Pathology"],"prefix":"10.1111","volume":"51","author":[{"given":"U.","family":"Dimri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,20]]},"reference":[{"key":"e_1_2_22_2_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0034-5288(18)32864-9","article-title":"Toxicity of Jatropha curcas in sheep and goats","volume":"21","author":"Ahmed O. M. M.","year":"1979","journal-title":"Res. Vet. Sci."},{"key":"e_1_2_22_3_1","first-page":"120","article-title":"Influence of some disease conditions on blood serum levels of antioxidant vitamins and some trace elements of Egyptian Balady Sheep in Assiut Governorate","volume":"42","author":"Ali A. A.","year":"2000","journal-title":"Assiut Vet. Med. J."},{"key":"e_1_2_22_4_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-32.4.711"},{"key":"e_1_2_22_5_1","first-page":"152","article-title":"The prevention of fowl cholera, with aqueous extracts of plants, in poultry production","volume":"8","author":"Carrillo C. M.","year":"1997","journal-title":"Agron. Mesoam."},{"key":"e_1_2_22_6_1","volume-title":"Veterinary Clinical Pathology","author":"Coles E. H.","year":"1980"},{"key":"e_1_2_22_7_1","first-page":"135","article-title":"Therapeutic efficacy of AV\/EPP\/14 herbal ectoparasiticide against sarcoptic mange infectation in rabbits","volume":"12","author":"Das S. S.","year":"1998","journal-title":"J. Vet. Parasitol."},{"key":"e_1_2_22_8_1","first-page":"1397","article-title":"Advances in clinical dermatology","volume":"20","author":"DeBoer D. J.","year":"1990","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"e_1_2_22_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00305316.1974.10434888"},{"key":"e_1_2_22_10_1","first-page":"9","article-title":"Haemaphysalis (Allophysalis) garhwalensis\u2013 description of immature stage, host distribution and ecology","volume":"1","author":"Dhanda V.","year":"1977","journal-title":"Indian J. Parasitol."},{"key":"e_1_2_22_11_1","first-page":"320","volume-title":"Pacific Coast Ent. Soc","author":"Ferris G. E.","year":"1951"},{"key":"e_1_2_22_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/3278176"},{"key":"e_1_2_22_13_1","first-page":"42","article-title":"Prevalence and chemotherapy of sarcoptic mange in swine","volume":"19","author":"Galhotra A. P.","year":"1980","journal-title":"Haryana Vet."},{"key":"e_1_2_22_14_1","first-page":"157","volume-title":"Least Square Analysis of Data with Unequal Subclass Numbers","author":"Harvey W. R.","year":"1975"},{"key":"e_1_2_22_15_1","first-page":"29","article-title":"Mange problems are robbing feed efficiency","volume":"16","author":"Hogg A.","year":"1979","journal-title":"Hog. Farm. Manage."},{"key":"e_1_2_22_16_1","volume-title":"Schalm's Veterinary Hematology","author":"Jain N. C.","year":"1986"},{"key":"e_1_2_22_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1989.tb02213.x"},{"key":"e_1_2_22_18_1","first-page":"622","article-title":"Treatment of sarcoptic mange in goats with oil of Karanj","volume":"46","author":"Kale S. M.","year":"1969","journal-title":"Indian Vet. J."},{"key":"e_1_2_22_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8524(96)00157-5"},{"key":"e_1_2_22_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(02)00015-8"},{"key":"e_1_2_22_21_1","first-page":"219","article-title":"Effect of sheep blody louse (Damalinia ovis) on host weight gain and fleece value","volume":"2","author":"Kettle P. R.","year":"1974","journal-title":"N Z J Exp. Agric."},{"key":"e_1_2_22_22_1","first-page":"67","article-title":"Efficacy of herbal ectoparasiticide AV\/EPP\/14 against lice and tick infestation on buffalo and cattle","volume":"14","author":"Kumar R","year":"2000","journal-title":"J. Vet. Parasitol."},{"key":"e_1_2_22_23_1","first-page":"543","article-title":"Studies on the comparative efficacy of Cerdrus deodara oil, benzyl benzoate and tetraethylthiuram mono sulphide against sarcoptic mange in sheep","volume":"53","author":"Lal J.","year":"1976","journal-title":"Indian Vet. J."},{"key":"e_1_2_22_24_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0034-5288(18)30839-7","article-title":"Haematological and immunological response of unrestrained cattle to Psoroptes ovis, the sheep scab mite","volume":"44","author":"Losson B.","year":"1988","journal-title":"Res. Vet. Sci."},{"key":"e_1_2_22_25_1","first-page":"145","article-title":"Antifertility effect of Jatropha Curcas L. seed in guinea\u2010pigs","volume":"11","author":"Makonnen E.","year":"1997","journal-title":"Ethiop. J. Health Dev."},{"key":"e_1_2_22_26_1","first-page":"45","article-title":"Studies on life cycle of psoroptic mange mite in rabbits and chemotherapy under experimental conditions","volume":"13","author":"Maske D. K.","year":"1999","journal-title":"J. Vet. Parasitol."},{"key":"e_1_2_22_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(96)00005-7"},{"key":"e_1_2_22_28_1","first-page":"75","article-title":"Some studies on the blood constituents of sheep infested with biting louse Damalinia ovis","volume":"59","author":"Mehrotra P.","year":"1982","journal-title":"Indian Vet. J."},{"key":"e_1_2_22_29_1","first-page":"69","volume-title":"Clinical and Pathological Picture of Experimental Hasstilesia Infection","author":"Moiseenko K. G.","year":"1983"},{"key":"e_1_2_22_30_1","first-page":"168","article-title":"Raising of non\u2010specific resistance during Hasctilesia ovis infection in sheep","author":"Moisennko K. G.","year":"1984","journal-title":"Epizootologiya,-immunitet\u2013diagnostika-i.- Khimioprofilaktika-parazitozovsel'skokhozyaistvennykh-zhivotnykh \u2013v-kazakhstane, -sbornik Nauchnykh-Trudov"},{"key":"e_1_2_22_31_1","first-page":"194","volume-title":"Agglutination methods","author":"Moudgil K. D.","year":"1997"},{"key":"e_1_2_22_32_1","volume-title":"Indian Materia Medica","author":"Nadkarni A. K.","year":"1954"},{"key":"e_1_2_22_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00444-1"},{"key":"e_1_2_22_34_1","first-page":"155","article-title":"In vitro efficacy of herbal formulation AV\/EPP\/14 against dog tick Rhipicephalus sanguinesis","volume":"11","author":"Panda D. N.","year":"1997","journal-title":"J. Vet. Parasitol."},{"key":"e_1_2_22_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0921-4488(90)90021-W"},{"key":"e_1_2_22_36_1","first-page":"58","article-title":"Clinical and morphological features of sarcoptic mange in goats","volume":"12","author":"Pas'Ko G. G.","year":"1974","journal-title":"Veterinariya, Moscow"},{"key":"e_1_2_22_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.136.15.393"},{"key":"e_1_2_22_38_1","first-page":"50","article-title":"Efficacy of AV\/EPP\/14 (herbal ectoparasiticide) against canine demodicosis","volume":"12","author":"Pathak K. M. L.","year":"1998","journal-title":"J. Vet. Parasitol."},{"key":"e_1_2_22_39_1","first-page":"266","article-title":"Evaluation of the cell mediated immune response in goats employing 2,4\u2010dinitrochlorobenzene","volume":"12","author":"Rajan A.","year":"1981","journal-title":"Kerala J. Vet. Sci."},{"key":"e_1_2_22_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00573.x"},{"key":"e_1_2_22_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(98)01272-1"},{"key":"e_1_2_22_42_1","first-page":"125","article-title":"Evaluation of some acaricides in psoroptic mange in buffaloes","volume":"20","author":"Ruprah N. S.","year":"1980","journal-title":"Haryana Vet."},{"key":"e_1_2_22_43_1","first-page":"107","article-title":"Bioactivity of ethanol extract of karanja (Pongamia glabra vent) seed coat against mosquitoes","volume":"31","author":"Sagar S. K.","year":"1999","journal-title":"J. Commun. Dis."},{"key":"e_1_2_22_44_1","volume-title":"Indian Veterinary Research Institute","author":"Shah H.,","year":"1994"},{"key":"e_1_2_22_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-4488(97)00002-3"},{"key":"e_1_2_22_46_1","first-page":"261","article-title":"Therapeutic efficacy of mastilep in treating subclinical mastitis of variable etiology in lactating cows","volume":"77","author":"Sharma M.","year":"2000","journal-title":"Indian Vet. J."},{"key":"e_1_2_22_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(99)00031-3"},{"key":"e_1_2_22_48_1","first-page":"33","article-title":"Observation and the treatment of buffalo calves suffering from psoroptic mange and pyoderma","volume":"13","author":"Singh N.","year":"1989","journal-title":"Indian Vet. Med. J."},{"key":"e_1_2_22_49_1","volume-title":"Statistical Methods","author":"Snedecor G. W.","year":"1967"},{"key":"e_1_2_22_50_1","first-page":"495","volume-title":"Helminths, Arthropods and Protozoa of Domesticated Animals","author":"Soulsby E. J. L.","year":"1968"},{"key":"e_1_2_22_51_1","first-page":"266","article-title":"Evaluation of the comparative efficacy of various indigenous fly repellents against cutaneous myiasis producing flies","volume":"11","author":"Subramanian H.","year":"1980","journal-title":"Kerala J. Vet. Sci."},{"key":"e_1_2_22_52_1","first-page":"118","article-title":"Immunological problems in psoroptic mange in cattle, sheep and rabbits","volume":"39","author":"Uhlir J.","year":"1989","journal-title":"Veterinarstvi"},{"key":"e_1_2_22_53_1","first-page":"463","article-title":"Amitraz treatment of demodicosis in dog","volume":"67","author":"Yathiraj S.","year":"1991","journal-title":"Indian Vet. J."}],"container-title":["Journal of Veterinary Medicine Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0442.2004.00601.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0442.2004.00601.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:38:03Z","timestamp":1696894683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0442.2004.00601.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1111\/j.1439-0442.2004.00601.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0442.2004.00601.x","archive":["Portico"],"relation":{},"ISSN":["0931-184X"],"issn-type":[{"value":"0931-184X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}