{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:36:55Z","timestamp":1734500215059,"version":"3.30.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T00:00:00Z","timestamp":1087948800000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of the present study was to elucidate the effect of subclinical doses of<jats:italic>Escherichia coli<\/jats:italic>heat\u2010labile enterotoxin (LT) on the antro\u2010duodenal myoelectric activities of weaned pigs. Twelve weaned pigs were surgically implanted with three pairs of electrodes on the antrum 3\u2003cm before the pylorus, 5 and 20\u2003cm after the pylorus on the duodenum, respectively. An infusion cannula was inserted into the duodenum between duodenal electrodes. Using a wireless telemetry recording system, an electromyography (EMG) tracing lasting at least 24\u2003h was recorded as the control, then another 24\u2010h EMG recording was performed with a bolus intraduodenal infusion of LT (0.1 and 0.5\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg b.w.). After a 1\u2010 to 2\u2010day break, a 5\u2010fold higher dose of LT was administered using the same protocol. In the antrum, LT administration barely modified the EMG signal. However, in the duodenum it prolonged the duration of phase II and the migrating myoelectric complex (MMC) cycle when compared with the control. The number of duodenal MMC cycles was also significantly diminished. Moreover, the migrating velocity of phase III was increased. The migrating action potential complex (MAPC) was present both without and with LT, but occurred more frequently following LT administration. In conclusion, LT caused a dose\u2010dependent, lagged alteration in the duodenal MMC in weaned pigs, involving a reduction of the MMC number by lengthening phase II, increased phase III migration velocity, and increased MAPC frequency. The disturbances did not, however, result in diarrhoea and may reflect the induction of a local protection mechanism of the gut to expel unwanted foreign content from the lumen of the upper gut.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2004.00610.x","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T13:19:21Z","timestamp":1087996761000},"page":"106-112","source":"Crossref","is-referenced-by-count":3,"title":["Effect of<i>Escherichia coli<\/i>Heat\u2010labile Enterotoxin on the Myoelectric Activity of the Duodenum in Weaned Pigs"],"prefix":"10.1111","volume":"51","author":[{"given":"G.","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Woli\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zabielski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(99)00016-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1978.235.3.E311"},{"key":"e_1_2_11_4_1","first-page":"G57","article-title":"Alternation of myoelectric activity of small intestine by invasive Escherichia coli","volume":"238","author":"Burns T. 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