{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:00:02Z","timestamp":1761487202526,"version":"3.30.2"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T00:00:00Z","timestamp":1092700800000},"content-version":"vor","delay-in-days":77,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The purpose of the present study was to determine the most effective time interval between the administration of sufentanil long acting (LA) and the induction of sevoflurane anaesthesia in dogs. The occurrence of sedation, analgesia and other marked side\u2010effects were evaluated in addition to the possible dosage\u2010reducing effect of sufentanil on sevoflurane in dogs. Forty clinically normal beagles aged 1\u20132\u2003years and weighing between 8.4 and 13.6\u2003kg were included. Two control groups were used: one group of dogs (A) received sufentanil LA (50\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg i.m.) and a second group (B) the sufentanil vehicle followed by standard inhalation anaesthesia of 90\u2003min. After premedication with sufentanil LA immediately before (C<jats:sup>0<\/jats:sup>), 15\u2003min (D<jats:sup>15<\/jats:sup>) or 30\u2003min (E<jats:sup>30<\/jats:sup>) prior to induction with thiopental (i.v.) the dogs were anaesthetized for 90\u2003min with sevoflurane in oxygen. Pain and sedation scores were evaluated every 10\u2003min during sevoflurane anaesthesia and at 2 (<jats:italic>T<\/jats:italic><jats:sub>120<\/jats:sub>), 4 (<jats:italic>T<\/jats:italic><jats:sub>240<\/jats:sub>) and 24\u2003h (<jats:italic>T<\/jats:italic><jats:sub>1440<\/jats:sub>) after initiation of anaesthesia. The occurrence of adverse reactions such as hypothermia, lateral recumbency, ataxia, noise sensitivity, vomiting, defaecation, salivation, nystagmus and excitation was observed at the same time\u2010points. During the recovery period pain scores were lower and sedation scores higher in the sufentanil LA groups. In many dogs acceptable pain and sedation scores persisted during 24\u2003h. Several dogs showed ataxia, lateral recumbency, arousal on auditory stimulation, defaecation, salivation and excitation at several time\u2010points after sufentanil LA administration. Sufentanil LA in addition to sevoflurane anaesthesia offered beneficial dosage\u2010reducing analgesic effects up to 69.8% for thiopental and 78.3% for sevoflurane; although several typical opioid side\u2010effects occurred. To achieve this advantageous dosage\u2010reducing effect 15\u2003min should be respected between sufentanil LA administration and induction of sevoflurane anaesthesia.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2004.00628.x","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T14:23:45Z","timestamp":1092752625000},"page":"242-248","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010nociceptive and Sedative Effects of Sufentanil Long Acting during and after Sevoflurane Anaesthesia in Dogs"],"prefix":"10.1111","volume":"51","author":[{"given":"I.","family":"Polis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Moens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gasthuys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hoeben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tshamala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198909000-00005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0889-8537(21)00490-9","article-title":"Body temperature and anesthesia","volume":"9","author":"Bissonnette B.","year":"1991","journal-title":"Anesth. 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