{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:49:50Z","timestamp":1786787390535,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T00:00:00Z","timestamp":1107820800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Calcinosis circumscripta is an uncommon syndrome of ectopic idiopathic, dystrophic, metastatic or iatrogenic mineralization characterized by deposition of calcium salts in soft tissues. This paper is a retrospective study of 77 canine cases. The age of dogs in the study varied from 4\u2003months to 15\u2003years and 55% were &lt;1\u2003year old, 74% &lt;2\u2003years old and 88% &lt;4\u2003years old. Several pure and mixed, typically large breed dogs were affected so that 28.6, 13 and 9% were German Shepherd, Rottweiler and Labrador Retriever respectively. The size of lesions varied from 2\u2003mm to 13\u2003cm in diameter but most lesions were between 0.5\u2003cm and 3\u2003cm in diameter. Lesions were solitary in 82% of the affected dogs, and occurred most commonly on the hind feet (50%) and tongue (23%). With multiple lesions there was no apparent body symmetry. Microscopically, most lesions were well\u2010defined single or multiple variably sized aggregates of amorphous to granular, lightly to darkly basophilic material with or without peripheral granulomatous reaction and surrounded by varying amounts of fibrous connective tissue. Additionally, three small nodular masses in the wall of the jejunum of a dog were diagnosed as calcinosis circumscripta. This is the first reported case of idiopathic intestinal calcinosis circumscripta in the dog.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2004.00675.x","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T16:05:27Z","timestamp":1107878727000},"page":"13-17","source":"Crossref","is-referenced-by-count":55,"title":["Calcinosis Circumscripta in the Dog: A Retrospective Pathological Study"],"prefix":"10.1111","volume":"52","author":[{"given":"A. K.","family":"Tafti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Bourque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_20_2_1","first-page":"348","article-title":"Calcinosis circumscripta in a domestic short haired cat","volume":"77","author":"Anderson W. I.","year":"1987","journal-title":"Cornell Vet."},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.123.3.80"},{"key":"e_1_2_20_4_1","first-page":"381","article-title":"Calcinosis circumscripta of the tongue in a cat","volume":"78","author":"Anderson W. I.","year":"1988","journal-title":"Cornell Vet."},{"key":"e_1_2_20_5_1","first-page":"S63","article-title":"Familial precocious osteoarthritis (POA), spondyloepiphyseal (SED) and calcium pyrophosphate deposition disease (CPPD) linked to a point mutation in the type II procollagen gene (COL2A1)","volume":"36","author":"Basualo J.","year":"1993","journal-title":"Arth. Rheum."},{"key":"e_1_2_20_6_1","first-page":"9","article-title":"Calcinosis circumscripta in two cats","volume":"20","author":"Beroccal A.","year":"1992","journal-title":"Feline Pract."},{"key":"e_1_2_20_7_1","first-page":"243","article-title":"A review of soft tissue calcification","volume":"24","author":"Black A. S.","year":"1985","journal-title":"J. Foot Surg."},{"key":"e_1_2_20_8_1","first-page":"618","article-title":"Calcinosis circumscripta of the tongue in cattle","volume":"35","author":"Carrara O.","year":"1982","journal-title":"Atti. Sis. Vet."},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270610"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)34797-0"},{"key":"e_1_2_20_11_1","first-page":"107","article-title":"Apocrine cystic calcinosis in dogs and its relationship to chronic renal disease","volume":"57","author":"Cordy D. R.","year":"1967","journal-title":"Cornell Vet."},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(17)44452-6"},{"key":"e_1_2_20_13_1","first-page":"438","article-title":"Hyperphosphatemic tumoral calcinosis in a young dog with renal failure","volume":"35","author":"Croom A. L.","year":"1994","journal-title":"Can. Vet. J."},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-2-153"},{"key":"e_1_2_20_15_1","first-page":"542","article-title":"Multicentric periarticular calcinosis in a pup","volume":"177","author":"Ellison G. W.","year":"1980","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_2_20_16_1","first-page":"619","volume-title":"Textbook of Veterinary Internal Medicine","author":"Ettinger S. J.","year":"2000"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1996.tb02447.x"},{"key":"e_1_2_20_18_1","first-page":"507","article-title":"Cervical calcinosis circumscripta in three related Great Dane dogs","volume":"11","author":"Flo G. L.","year":"1975","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"e_1_2_20_19_1","first-page":"391","article-title":"Calcinosis circumscripta associated with Medroxyprogesterone in two Poodle bitches","volume":"28","author":"Ginel P. J.","year":"1992","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.136.2.44"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1997.tb00260.x"},{"key":"e_1_2_20_22_1","volume-title":"Veterinary Dermatopathology, a Macroscopic and Microscopic Evaluation of Canine and Feline Skin Diseases","author":"Gross T. L.","year":"1992"},{"key":"e_1_2_20_23_1","first-page":"663","article-title":"Calcinosis circumscripta involving the mammary glands of a New Zealand white rabbit","volume":"157","author":"Henderson J. D.","year":"1970","journal-title":"J. Am. Vet. Assoc."},{"key":"e_1_2_20_24_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/030098587901600213","article-title":"Calcinosis circumscripta in the buffalo","volume":"16","author":"Ikede B. O.","year":"1979","journal-title":"Vet. Pathol."},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03687.x"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1989.tb01073.x"},{"key":"e_1_2_20_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199601150-00017"},{"key":"e_1_2_20_28_1","first-page":"1192","article-title":"Calcinosis circumscripta in a dog","volume":"164","author":"Legendre A. M.","year":"1974","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1990.tb00654.x"},{"key":"e_1_2_20_30_1","first-page":"616","article-title":"Calcinosis cirumscripta in two rhesus monkeys","volume":"34","author":"Line S. W.","year":"1984","journal-title":"Lab. Anim. Sci."},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.130.26.575"},{"key":"e_1_2_20_32_1","first-page":"72","article-title":"Resolution of quadriparesis caused by cervical tumor calcinosis in a dog","volume":"27","author":"Marks S. L.","year":"1991","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.1.0162"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.144.2.52"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2001.tb14575.x"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1967.tb04553.x"},{"key":"e_1_2_20_37_1","first-page":"14","volume-title":"Pathology of Domestic Animals","author":"Palmer N.","year":"1993"},{"key":"e_1_2_20_38_1","first-page":"291","article-title":"Disseminated calcinosis cutis in a dog","volume":"161","author":"Pool R. R.","year":"1972","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_2_20_39_1","first-page":"651","article-title":"Idiopathic calcinosis circumscripta in the dog: a retrospective analysis of 130 cases","volume":"24","author":"Scott D. W.","year":"1988","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"e_1_2_20_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1961.tb03815.x"},{"key":"e_1_2_20_41_1","first-page":"363","article-title":"Calcium pyrophosphate deposition disease in a Fox Terrier","volume":"29","author":"Short R. P.","year":"1993","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"e_1_2_20_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb02999.x"},{"key":"e_1_2_20_43_1","first-page":"1643","article-title":"The pathologic mineralization of soft tissue: calcinosis circumscripta in horses","volume":"12","author":"Stone W. C.","year":"1990","journal-title":"Comp. Cont. Edu. Pract. Vet."},{"key":"e_1_2_20_44_1","first-page":"265","article-title":"Calcinosis circumscripta: a histochemical study of the lesion in man, dogs and a monkey","volume":"49","author":"Thompson S. W.","year":"1959","journal-title":"Cornell Vet."},{"key":"e_1_2_20_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588201900503"},{"key":"e_1_2_20_46_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-4-346"},{"key":"e_1_2_20_47_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-37.4.813"}],"container-title":["Journal of Veterinary Medicine Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0442.2004.00675.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0442.2004.00675.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T15:41:46Z","timestamp":1696952506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0442.2004.00675.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1111\/j.1439-0442.2004.00675.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0442.2004.00675.x","archive":["Portico"],"relation":{},"ISSN":["0931-184X"],"issn-type":[{"value":"0931-184X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}