{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:59:23Z","timestamp":1770217163211,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systolic pulmonary arterial hypertension (PAH) was diagnosed in a 15\u2010year\u2010old intact male Yorkshire terrier presented for progressive dyspnoea and coughing. Several examinations were performed (thoracic radiographs, faecal analysis, heartworm antigen test, tracheal fluoroscopy, abdominal ultrasound, complete blood cell count, urine and serum biochemistry) but the PAH remained of unknown origin. Despite medical treatment (diuretics and angiotensin\u2010converting enzyme inhibitor), cardiovascular and respiratory signs dramatically worsened over a 1\u2010month period, with several daily syncope, cyanosis and tachypnoea at rest requiring permanent oxygen therapy. Oral tadalafil (Cialis<jats:sup>\u00ae<\/jats:sup>), a new long\u2010acting phosphodiesterase\u20105 inhibitor, belonging to the same family as sildenafil (Viagra<jats:sup>\u00ae<\/jats:sup>), was added to the background therapy. The condition of the dog improved quickly (&lt;24\u2003h), and short\u2010term follow up (7\u2003days) showed a decrease in systolic pulmonary arterial pressure up to 26\u2003mmHg concomitant with the disappearance of all respiratory and cardiac signs of PAH (cyanosis, syncope and tachypnoea). This case is of interest because it concerns the first reported short\u2010term use of tadalafil in canine PAH. However, long\u2010term studies with a large number of diseased animals are now required before prescription by general practitioners could be recommended.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2006.00800.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T13:02:35Z","timestamp":1141822955000},"page":"129-133","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of Oral Tadalafil, a New Long\u2010acting Phosphodiesterase\u20105 Inhibitor, for the Short\u2010term Treatment of Pulmonary Arterial Hypertension in a Dog"],"prefix":"10.1111","volume":"53","author":[{"given":"F.","family":"Serres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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