{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:54:54Z","timestamp":1722455694529},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ten multiparous lactating sows were used to investigate whether intramammary infusion of lipopolysaccharides (LPS;<jats:italic>Escherichia coli<\/jats:italic>0111:B4; 2.0\u2003<jats:italic>\u03bc<\/jats:italic>g\/kg of body weight) would affect the circulating concentrations of Ca, P, 25\u2010hydroxyvitamin D (25\u2010OHD), tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>(TNF\u2010<jats:italic>\u03b1<\/jats:italic>), interleukin\u20106 (IL\u20106) and cortisol. The sows were randomly allotted to either control group (control) or LPS\u2010treated group with five individuals per group and were infused with either physiological saline solution or LPS solution. The rectal temperature and udder quarter appearance were recorded at 0 (just before infusion), 1, 3, 7, 12 or 24\u2003h after infusion. Blood samples were taken at 0, 1, 3, 7, 12 or 24\u2003h after infusion. Before infusion, the rectal temperatures of all sows were below 39.2\u00b0C. At 3 and 7\u2003h after infusion, the sows in the LPS group had a rectal temperature over 39.4\u00b0C. At 24\u2003h after infusion, the rectal temperatures returned to pre\u2010infusion levels. Serum Ca and P concentrations in the LPS group decreased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) after LPS infusion compared with the control group at 1\u2003h after infusion. No significant differences (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05) in the concentrations of 25\u2010OHD were observed between groups control and LPS at any sampling time. Increased (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) concentrations of serum TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106 and cortisol were observed in the LPS group compared with the control group at 3 and 7\u2003h after infusion respectively. In conclusion, the elevation of serum concentrations of TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106 and cortisol and the alterations of circulating concentrations of Ca and P following LPS infusion indicate that the immune system has been activated and immune activation may affect macromineral homeostatic regulation, which might have important implications for metabolic health of lactating sows. Lowered serum Ca and P following immune activation also shows a causative mechanism whereby immune activation increases the risk of secondary disorders such as mastitis\u2010metritis\u2010agalactia syndrome. However, immune activation did not affect circulating concentrations of vitamin D metabolites.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2006.00804.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T13:02:35Z","timestamp":1141822955000},"page":"113-118","source":"Crossref","is-referenced-by-count":12,"title":["The Influence of Intramammary Lipopolysaccharide Infusion on Serum Ca, P, Vitamin D, Cytokines and Cortisol Concentrations in Lactating Sows"],"prefix":"10.1111","volume":"53","author":[{"given":"J. F.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. G.","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Y.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115755"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2004.04.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(95)05536-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2527\/2002.801202x","article-title":"Circulating cortisol, tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, and interferon\u2010\u03b3 in pigs infected with Actinobacillus pleuropneumoniae","volume":"80","author":"Balaji R.","year":"2002","journal-title":"J. Anim. Sci."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.3.463-472.2004"},{"key":"e_1_2_6_7_1","first-page":"791","article-title":"Chemotactic activities in nonmastitic and mastitic mammary secretions: Presence of interleukin\u20108 in mastitic but not nonmastitic secretions","volume":"6","author":"Barber M.","year":"1998","journal-title":"Clin. Diag. Lab. Immunol."},{"key":"e_1_2_6_8_1","first-page":"457","volume-title":"Diseases of Swine","author":"Bertschinger H. U.","year":"1999"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2003023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1128\/IAI.67.8.4231-4236.1999","article-title":"Interleukin\u20101 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide","volume":"67","author":"Chiang C.","year":"1999","journal-title":"Infect. Immunol."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(85)81109-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2527\/2003.8151166x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/BF03547815","article-title":"Endotoxin\u2010effects of vaccination with Escherichia coli vaccines in the pig","volume":"39","author":"Garcia P.","year":"1998","journal-title":"Acta Vet. Scand."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(91)78597-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77140-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.463"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00077-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(98)00016-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3915-3922.2002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1988.9694158"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2460\/ajvr.1994.55.06.785","article-title":"Effect of mimicking prepartum concentration of estradiol\u201017\u03b2 on the inflammatory response to endotoxin in gilts","volume":"55","author":"Magnusson U.","year":"1994","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30710-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(97)90209-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.73.4.235"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/BF03548096","article-title":"A long term study on the health status and performance of sows on different feed allowances during late pregnancy. III. Escherichia coli and other bacteria, total cell content, polymorphonuclear leucocytes and pH in colostrums and milk during the first 3\u2003weeks of lactation","volume":"37","author":"Persson A.","year":"1996","journal-title":"Acta Vet. Scand."},{"key":"e_1_2_6_26_1","first-page":"555","article-title":"Effects of lipid A on calcium homeostasis in renal proximal tubules","volume":"276","author":"Proksch J. W.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(87)80099-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119492"},{"key":"e_1_2_6_29_1","first-page":"406","article-title":"Effect of E. coli ectotoxin on calcium and phosphate concentration in serum of dairy cows","volume":"36","author":"Sandstedt H.","year":"1984","journal-title":"Nord. Vet. Med."},{"key":"e_1_2_6_30_1","first-page":"319","article-title":"A hospital\u2010based study of the relationship between retained placenta and mastitis in dairy cows","volume":"79","author":"Schukken Y. H.","year":"1989","journal-title":"Cornell Vet."},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2460\/ajvr.1993.54.01.80","article-title":"Cytokine production during endotoxin\u2010induced mastitis in lactating cows","volume":"54","author":"Shuster D. E.","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2460\/ajvr.1993.54.01.80","article-title":"Cytokine production during endotoxin\u2010induced mastitis in lactating dairy cows","volume":"54","author":"Shuster D. E.","year":"1993","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_6_33_1","volume-title":"SAS\/STAT User's Guide (Release 6.03)","author":"Statistical Analysis Systems Institute","year":"1990"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1997.1215"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30758-1"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.7260"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1995.9694530"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(03)73948-4"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.2527\/1997.7561514x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.567"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2527\/2000.7871892x"}],"container-title":["Journal of Veterinary Medicine Series A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0442.2006.00804.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0442.2006.00804.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T07:07:23Z","timestamp":1706944043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0442.2006.00804.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1439-0442.2006.00804.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0442.2006.00804.x","archive":["Portico"],"relation":{},"ISSN":["0931-184X"],"issn-type":[{"value":"0931-184X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3,8]]}}}