{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:23:56Z","timestamp":1767374636339,"version":"3.32.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study tested and compared the anti\u2010proliferative and proliferative activities of two anti\u2010oestrogens and three anti\u2010progestins on four separate mouse model systems: young intact and adult ovariectomized (OV\u2010X) females, and young intact and adult castrated males. Pure steroidal anti\u2010oestrogen ICI 182,780 (ICI) decreased mammary and uterine growth stimulated by endogenous hormones in young intact females and by exogenous hormones [progesterone (Prog), 17<jats:italic>\u03b2<\/jats:italic>\u2010oestradiol (E) or E plus Prog] in both young intact and adult ovariectomized (OV\u2010X) females. Non\u2010steroidal anti\u2010oestrogen EM\u2010800 (EM), on the other hand, had no effect on mammary and uterine growth stimulated by endogenous hormones in young intact females and in adult OV\u2010X females. Uterine growth was even stimulated by EM alone, and a combination of EM plus Prog not only stimulated uterine growth but also mammary growth (an oestrogenic agonistic activity). However, EM showed anti\u2010oestrogenic activities in both mammary and uterine tissues in females treated with E or E plus Prog. In males, ICI and EM decreased mammary growth stimulated by exogenous hormones (E or E plus Prog) in both young intact and adult castrated animals. In young intact, but not in adult castrated males, ICI increased seminal vesicle growth affected by both endogenous and exogenous (Prog, E or E plus Prog) hormones. EM, on the other hand, decreased seminal vesicle weights in E or E plus Prog and increased its weights in Prog\u2010treated young intact males. Thus, under certain conditions EM possess mixed agonist and antagonist activity in the mammary gland, uterus and seminal vesicles. Norethindrone acetate (NA)\u2010stimulated mammary growth was decreased by anti\u2010progestins onapristone (ON), RU 46556 (RU), and RU 38486 (MI) by 34\u201359% in females and by 35\u201393% in males. Uterine weights of NA\u2010treated females were decreased by ON and RU by 29\u201355% but not by MI. In NA\u2010treated young intact males, seminal vesicle weights were stimulated by RU (by 63%) and not affected by ON and MI. In NA\u2010treated adult castrated males, seminal vesicle weights were decreased by ON, increased by RU and not affected by MI. The results obtained in these and our earlier studies show clearly that mouse four\u2010model systems could serve as<jats:italic>in vivo<\/jats:italic>tool for the detection of steroid hormone agonist and antagonist activities of natural and man\u2010made chemicals.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2006.00805.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T13:02:35Z","timestamp":1141822955000},"page":"145-153","source":"Crossref","is-referenced-by-count":9,"title":["Mouse Bioassay for<i>in vivo<\/i>Screening of Oestrogen and Progesterone Antagonists"],"prefix":"10.1111","volume":"53","author":[{"given":"J.","family":"\u0160Karda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"K\u00f6hlerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"81","article-title":"Oestrogenic effects of ICI 182,780, a putative anti\u2010estrogen on the secretion of oxytocin and prostaglandin F2\u03b1 during oestrus cycle in the intact ewe","volume":"51","author":"Al\u2010Matubsi H.","year":"1998","journal-title":"Anim. 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