{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T14:19:05Z","timestamp":1725373145569},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pathology of the colon in pigs infected with<jats:italic>Trichuris suis<\/jats:italic>and fed an inulin and a non\u2010inulin containing diet was studied to investigate the inflammatory response induced and the influence of inulin on this. Twenty\u2010nine pigs were allocated into four groups (N\u20107, I\u20107, N\u20109 and N\/I\u20109). Groups N\u20107, N\u20109 and N\/I\u20109 were given a diet with non\u2010fermentable carbohydrates, and group I\u20107 was fed a diet including fermentable carbohydrates (inulin). After 2\u2003weeks, all pigs were inoculated with 2000<jats:italic>T.\u00a0suis<\/jats:italic>eggs. Seven weeks post\u2010infection (p.i.), groups N\u20107 and I\u20107 were killed and group N\/I\u20109 changed to inulin diet to study the influence of inulin on already established<jats:italic>T.\u00a0suis<\/jats:italic>. Nine weeks p.i., groups N\u20109 and N\/I\u20109 were killed.<jats:italic>Trichuris suis<\/jats:italic>were collected from the colon for enumeration. Tissues from the colon of each pig were taken for histological and immunohistochemical quantitative and semi\u2010quantitative evaluations of heterophils, eosinophils, mast cells, IgA<jats:sup>+<\/jats:sup>, IgG<jats:sup>+<\/jats:sup>, IgM<jats:sup>+<\/jats:sup>and CD3<jats:sup>+<\/jats:sup>cells. The findings were compared with tissues from seven uninfected pigs of the same age. Pigs fed inulin had significantly fewer worms compared with pigs on the non\u2010fermentable carbohydrate diet. The number of inflammatory cells in the colonic mucosa was increased in all<jats:italic>T.\u00a0suis<\/jats:italic>\u2010infected pigs compared with uninfected controls. The numbers of eosinophils, mast cells, IgA<jats:sup>+<\/jats:sup>, IgG<jats:sup>+<\/jats:sup>and CD3<jats:sup>+<\/jats:sup>cells were significantly lower in pigs fed inulin than pigs fed non\u2010fermentable carbohydrate. Whether this is a direct effect of inulin or a secondary effect due to the lower parasitic burden in inulin fed pigs is not known.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2006.00861.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T14:42:44Z","timestamp":1158072164000},"page":"405-409","source":"Crossref","is-referenced-by-count":7,"title":["Pathology of<i>Trichuris suis<\/i>Infection in Pigs Fed an Inulin\u2010 and a Non\u2010inulin\u2010containing Diet"],"prefix":"10.1111","volume":"53","author":[{"given":"L.","family":"Krag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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