{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:38:42Z","timestamp":1762605522923},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T00:00:00Z","timestamp":1196121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine Series A"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hydroxyethyl starch (HES) solution is an effective colloidal infusion solution in humans for treatment of hypovolaemic shock, but it has not been compared with fluids currently available for use in horses. On the basis of plasma\u2010expanding effect of HES in normal horses, a 10% medium\u2010molecular 200\/0.5 solution of HES was subsequently tested in hypovolaemic horses. Six normal horses were given five protocols of a single infusion of HES at varying dosage rates (5, 10, 15\u2003ml HES\/kg), as well as isotonic saline (15\u2003ml\/kg) and hypertonic saline (4\u2003ml\/kg b.w.). Dehydrated horses suffering from acute colitis or those which had been treated surgically for ileus of the small or large intestine were given an i.v. infusion of 10\u2003ml HES\/kg in combination with 10\u2003ml saline\/kg. Clinical data and blood samples for testing were taken before the infusion, and then 10\u2003min, 1\u2003h, 2, 4, 6, 8, 10, 12 and 24\u2003h after infusion (a.i.). A significant decrease in haematocrit was observed in protocol 1\u20135 for a period of up to 4, 4, 10\u2003h, 10\u2003min and up to 10\u2003min; in group of colitis, during the entire 24\u2010h testing period, and in groups of ileus of small intestine and of large intestine, up to 4 and 10\u2003h a.i. HES decreases better and longer\u2010lasting haematocrit and total protein than either isotonic or hypertonic saline. Half\u2010life of HES increases due to higher dosage (5.83, 7.63 and 11.48\u2003h) and distribution is exclusively intravascular. In normal horses of protocol 1\u20133 using HES aPTT, sodium and potassium were within the physiological range. Serum amylase activity is increased in horses using HES. On the basis of this clinical study, the decreasing effect of urea and creatinine in colic patients after surgery and fewer instances of postoperative ileus a dosage of 10\u2003ml HES\/kg could be recommended.<\/jats:p>","DOI":"10.1111\/j.1439-0442.2007.01007.x","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:37:58Z","timestamp":1196728678000},"page":"592-598","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Hydroxyethyl Starch Solution in Normal Horses and Horses with Colic or Acute Colitis"],"prefix":"10.1111","volume":"54","author":[{"given":"G. F.","family":"Schusser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rieckhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. R.","family":"Ungemach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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