{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T18:46:29Z","timestamp":1763232389237},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T00:00:00Z","timestamp":1088553600000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine, Series B"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This experimental study was designed to compare the acquired resistance in pigs to <jats:italic>Ascaris suum<\/jats:italic> eggs following 4\u2010weekly oral immunizations with either 200 <jats:italic>A. suum<\/jats:italic> infective eggs or 50 <jats:italic>A. suum<\/jats:italic> third stage larvae (L3). The two immunized groups (<jats:italic>n<\/jats:italic>\u2003=\u20037) together with an unimmunized control group (<jats:italic>n<\/jats:italic>\u2003=\u20037) of pigs were challenged orally with 50 infective <jats:italic>A. suum<\/jats:italic> eggs per kilogram bodyweight on day 19 after the last immunization. Seven days post\u2010challenge the group immunized with eggs showed signs of resistance as evidenced by reduced lung larval counts compared with the challenge control group. Such significant resistance was not observed in the L3\u2010immunized group. However, a markedly increased inflammatory liver reaction and white spot formation was demonstrated in the L3\u2010immunized pigs after challenge compared with both control animals and egg\u2010immunized pigs. On the day of challenge only the egg\u2010immunized pigs mounted an anti\u2010<jats:italic>Ascaris<\/jats:italic> antibody response both in serum and in lung lavage fluid. <jats:italic>Ascaris<\/jats:italic>\u2010antigen induced increased histamine release from peripheral leucocytes following both immunization and challenge could only be demonstrated in the egg\u2010immunized pigs. On day 7 post\u2010challenge local IgA\u2010anti\u2010<jats:italic>Ascaris<\/jats:italic> antibodies were further demonstrated in bile of the egg\u2010immunized group and in the small intestine of both immunized groups. In conclusion, oral <jats:italic>A. suum<\/jats:italic> egg immunization of pigs induced a significant reduction in lung larval counts upon challenge. In contrast, oral L3 immunization seemed to prime the pigs as observed by the presence of stunted lung larval growth and increased liver reaction post\u2010challenge with <jats:italic>A. suum<\/jats:italic> eggs.<\/jats:p>","DOI":"10.1111\/j.1439-0450.2004.00752.x","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T06:17:07Z","timestamp":1088749027000},"page":"185-190","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Studies of Experimental Oral Inoculation of Pigs with <i>Ascaris suum<\/i> Eggs or Third Stage Larvae"],"prefix":"10.1111","volume":"51","author":[{"given":"L.","family":"Eriksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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