{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:50:28Z","timestamp":1761126628224},"reference-count":13,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"vor","delay-in-days":3147,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Zusammenfassung. <\/jats:bold> Pilzerkrankungen des Ohres werden am h\u00e4ufigsten als Geh\u00f6rgangsmykose beschrieben. Ziel unserer Untersuchungen war die Frage nach der Art der Besiedlung im Ohr bei immunkompetenten Patienten. Von 1993 bis 2000 wurden 128 Patienten mit Verdacht auf Otomykose untersucht. 115 Patienten litten an chronischer Otitis media bei persistierender Trommelfellperforation und Ohrsekretion. 13 weitere Patienten hatten klinische Zeichen einer Otitis externa. Bei 59 Patienten wurde eine Geh\u00f6rgangsmykose diagnostiziert, bei f\u00fcnf auch eine Pilzinfektion des Mittelohres. Von 139 Proben wurden im Geh\u00f6rgang 54\u2010mal, am Trommelfell f\u00fcnfmal und im Mittelohr f\u00fcnfmal Pilze nachgewiesen. Zu 2\/3 wurden Schimmelpilze und zu 1\/3 Hefen isoliert. Dabei dominierten <jats:italic>Aspergillus niger<\/jats:italic> und <jats:italic>Candida parapsilosis.<\/jats:italic> Bei Mastoiditis oder Cholesteatomverdacht wurden Proben von 15 Patienten entnommen und histologisch nach Pilzf\u00e4rbung untersucht. Bei vier Patienten wurden Pilzelemente neben der Kultur auch in histologischen Pr\u00e4paraten vom Mittelohr nachgewiesen. Die Pilzhyphen fanden sich in den Hohlr\u00e4umen des Mittelohres oder zwischen den Hornlamellen des Cholesteatoms. Im Mittelohr immunkompetenter Patienten fand sich eine chronisch\u2010hyperplastische (polyp\u00f6se) Entz\u00fcndung mit starker Sekretion, was wahrscheinlich Ansiedlung und saprophyt\u00e4res Wachstum der Pilze sowohl im Mittelohr als auch im Geh\u00f6rgang f\u00f6rdert. Invasives Pilzwachstum in das subepitheliale Bindegewebe hinein wurde nicht beobachtet.<\/jats:p><jats:p><jats:bold>Summary. <\/jats:bold> Fungal infections of the ear are mostly described as mycoses of the auditory canal. The aim of our investigations was to find out how fungi colonize the ear in immunocompetent patients. In the years from 1993 to 2000, 128 patients suspected of having otomycosis were examined. Of these 115 patients suffered from chronic otitis media with persisting tympanum perforation and otorrhea. A further 13 patients had clinical signs of otitis externa only. In 54 out of 139 samples, fungi were found in the auditory canal, in five on the tympanic membrane, and in five in the middle ear. Two\u2010thirds were isolated as moulds and one\u2010third as yeasts. Dominating species were <jats:italic>Aspergillus niger<\/jats:italic> and <jats:italic>Candida parapsilosis.<\/jats:italic> Samples of 15 patients suspected of having mastoiditis or cholesteatoma were examined histologically. Fungal hyphae were observed in the middle ear cavity and\/or between horny lamellae of cholesteatoma in 4 patients. In the middle ear of immunocompetent patients chronic\u2010hyperplastic (polypous) inflammation was detected with increased production of mucus, which probably promotes the colonization with pathogenic fungi as in the middle ear just like in the auditory canal.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2002.tb04546.x","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T10:02:18Z","timestamp":1302775338000},"page":"47-52","source":"Crossref","is-referenced-by-count":2,"title":["Histologische Untersuchungen bei Otomykosen*"],"prefix":"10.1111","volume":"45","author":[{"given":"Irina","family":"Vennewald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sch\u00f6nlebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Klemm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.1052"},{"key":"e_1_2_1_3_2","first-page":"493","article-title":"Calcium oxalate crystal deposition in necrotizing otomycosis caused by Aspergillus niger","volume":"6","author":"Landry M. M.","year":"1993","journal-title":"Mod Pathol"},{"key":"e_1_2_1_4_2","first-page":"561","article-title":"Aspergillus mastoiditis in acquired immunodeficiency syndrome","volume":"20","author":"Chen D.","year":"1999","journal-title":"Am J Otol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(94)90045-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008399"},{"key":"e_1_2_1_7_2","first-page":"760","article-title":"Zur Pilzflora des gesunden \u00e4u\u00dferen Geh\u00f6rganges","volume":"153","author":"Sch\u00f6nborn C.","year":"1967","journal-title":"Dermatol Wochenschr"},{"key":"e_1_2_1_8_2","first-page":"215","article-title":"Otitis externa \u2014 the clinical pattern in a tertiary institution in Singapore","volume":"27","author":"Loh K. S.","year":"1998","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001060050003"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436569"},{"key":"e_1_2_1_11_2","first-page":"362","article-title":"Beitrag zum Problem der Otomykosen","volume":"6","author":"Fendel K.","year":"1958","journal-title":"HNO"},{"issue":"2","key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1439-0507.1999.tb00010.x","article-title":"Fungal colonization of the paranasal sinuses","volume":"42","author":"Vennewald I.","year":"1999","journal-title":"Mycoses"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00455140","article-title":"Reaktionsformen der Mittelohrschleimhaut","volume":"216","author":"Arnold W.","year":"1977","journal-title":"Arch Otorhinolaryngol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-285"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2002.tb04546.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2002.tb04546.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T13:41:47Z","timestamp":1700314907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2002.tb04546.x"}},"subtitle":["Histological studies in otomycosis"],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":13,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1111\/j.1439-0507.2002.tb04546.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2002.tb04546.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}