{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:09:40Z","timestamp":1700352580244},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"vor","delay-in-days":3147,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p><jats:bold>Zusammenfassung. <\/jats:bold> Die Aktivierung der Blutgerinnung tritt in unterschiedlichem Ma\u00df bei invasiven einheimischen Mykosen auf. W\u00e4hrend es bei Candidosen und Aspergillosen nach Einbruch der Pilze in die Blutbahn gelegentlich zur Bildung von Thromben kommt, die zu septischen Embolien Anlass geben k\u00f6nnen, werden bei Mucormykosen (Syn. Zygomykosen) regelm\u00e4\u00dfig ausgedehnte thrombotische Verschl\u00fcsse der befallenen Gef\u00e4\u00dfe und folglich Nekrosen des abh\u00e4ngigen Gewebes beobachtet. F\u00fcr die Ausl\u00f6sung der Gerinnung durch <jats:italic>Candida<\/jats:italic> und Aspergillen k\u00f6nnen sekretorische Aspartat\u2010Proteinasen der Pilze verantwortlich sein, die den Gerinnungsfaktor X aktivieren, wie bereits fr\u00fcher gezeigt wurde [1, 2]. F\u00fcr die gravierenden Gerinnungsereignisse bei Mucormykosen ist hingegen offenbar eine extrazellul\u00e4re subtilisin\u2010\u00e4hnliche Serinproteinase (Arp) verantwortlich, die bereits in geringen Konzentrationen bei Raumtemperatur eine Parakoagulation von Fibrinogen ausl\u00f6st, und die zugleich den wichtigsten Inhibitor der Gerinnung, das Antithrombin III, zerst\u00f6rt. Neue Befunde zur Wirkung von Arp werden diskutiert.<\/jats:p><jats:p><jats:bold>Summary. <\/jats:bold> Activation of blood coagulation to a varying extent affect the course of domestic invasive mycoses. Upon invasion of blood vessels by <jats:italic>Candida<\/jats:italic> or aspergilli, occasionally thrombi are formed, which may cause septic embolism. In the course of mucormycosis (syn. zygomycosis) thrombotic occlusion of afflicted blood vessels and subsequent necrosis of dependent tissue regularly occurs. Coagulation during candidosis or aspergillosis may be triggered by secreted aspartic proteinases which are able to activate factor X as has been shown previously [1, 2]. During mucormycosis, severe blood coagulation apparently is due to paracoagulation of fibrinogen which is triggered by low concentrations of extracellular fungal subtilisin\u2010like proteinase (Arp). The enzyme is also able to inactivate the major inhibitor of blood coagulation (antithrombin III). Recent findings on the action of Arp are discussed.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2002.tb04547.x","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T10:02:18Z","timestamp":1302775338000},"page":"53-56","source":"Crossref","is-referenced-by-count":2,"title":["Beobachtungen zur Blutgerinnung bei einheimischen tiefen Mykosen"],"prefix":"10.1111","volume":"45","author":[{"given":"Maria","family":"Ntefidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Elsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Spreer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Weinstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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