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F\u00fcr die Aspergillose und vor allem die Candidose ist zur Zeit eine Aussage nur bei Kombination mehrerer Methoden m\u00f6glich. Entz\u00fcndungsparameter wie das Procalcitonin und C\u2010reaktive Protein sowie die proinflammatorischen Cytokine k\u00f6nnen wichtige Hinweise auf eine Infektion geben. Antigennachweise haben durch eine erh\u00f6hte Empfindlichkeit an Bedeutung gewonnen. Neben dem Mannan\u2010Nachweis im ELISA\u2010Test ist auch auf die Nachweise des <jats:italic>\u03b2<\/jats:italic>\u2010Glucans und des D\u2010Arabinitols aufmerksam zu machen. Ob die transmembranalen Rezeptorproteine oder andere regulatorische Proteine eine diagnostische Bedeutung erlangen, erscheint bei dem heutigen Stand der Forschung auf dem Gebiet der Proteomics nicht ausgeschlossen zu sein.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2004.01042.x","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T16:02:58Z","timestamp":1099670578000},"page":"60-65","source":"Crossref","is-referenced-by-count":0,"title":["Fr\u00fchsignale systemischer Mykosen \u2013 Leitlinien f\u00fcr 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