{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:08:55Z","timestamp":1772752135740,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T00:00:00Z","timestamp":1113350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Blastoschizomyces capitatus<\/jats:italic> (formerly known as <jats:italic>Geotrichum capitatum<\/jats:italic> and <jats:italic>Trichosporon capitatum<\/jats:italic>) is a rare, yet an emerging, cause of invasive infections in immunosuppressed patients. Profound and prolonged neutropenia is the crucial predisposing factor for this yeast infection. <jats:italic>Blastoschizomyces capitatus<\/jats:italic> was isolated from peripheral blood cultures of a profoundly neutropenic patient with acute myeloid leukemia (M2 FAB). Despite administration of antifungal chemotherapy with liposomal amphotericin B at 4.5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> daily, the patient succumbed 4\u2003days after initiation of treatment. Infections attributed to <jats:italic>B. capitatus<\/jats:italic> have generally a poor prognosis, although the yeast shows <jats:italic>in vitro<\/jats:italic> susceptibility to antifungal agents. Low flucytosine, caspofungin acetate, voriconazole and amphotericin B minimum inhibitory concentration values were also recorded with our isolate. The clinical relevance of the <jats:italic>in vitro<\/jats:italic> susceptibility testing against the isolate and the current antifungal chemotherapy regimens against <jats:italic>B. capitatus<\/jats:italic> systemic infections are discussed.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2005.01098.x","type":"journal-article","created":{"date-parts":[[2005,4,13]],"date-time":"2005-04-13T17:21:52Z","timestamp":1113412912000},"page":"216-220","source":"Crossref","is-referenced-by-count":29,"title":["Fatal <i>Blastoschizomyces capitatus<\/i> sepsis in a neutropenic patient with acute myeloid leukemia: first documented case from Greece"],"prefix":"10.1111","volume":"48","author":[{"given":"G.","family":"Christakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Perlorentzou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aslanidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Megalakaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Velegraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90334-5"},{"key":"e_1_2_5_3_2","first-page":"375","article-title":"Blastoschizomyces capitatus a new combination","volume":"22","author":"Salkin IF","year":"1985","journal-title":"Mycotaxon"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1977.03630210066020"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00699.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1989.tb02184.x"},{"key":"e_1_2_5_7_2","first-page":"96","article-title":"Trichosporon capitatum septicemia. Apoposos of 5 cases","volume":"33","author":"Herbrecht R","year":"1992","journal-title":"Agressologie"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01972503"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00068.x"},{"key":"e_1_2_5_10_2","volume-title":"Program and Abstracts of the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy","author":"Gurgui M","year":"2003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009053556"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.4.570"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/380643"},{"key":"e_1_2_5_14_2","first-page":"673","article-title":"Embolisch\u2010metastatische Pilz\u2010enzephalitis durch Trichosporon capitatum nach infusions therapie","volume":"35","author":"Deicke P","year":"1980","journal-title":"Deutsche Gesundhitswesen"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.5.1041"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.30.9.2318-2322.1992"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.9.2927-2930.1999"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200201243460410"},{"key":"e_1_2_5_19_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts","author":"National Committee for Clinical Laboratory Standards","year":"2002"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(03)00161-4"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3117-3119.2004"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00842.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.113"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/339215"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.21.3699"},{"key":"e_1_2_5_27_2","first-page":"62","volume-title":"Abstracts of the 8th Congress of the European Confederation of Medical Mycology\u2010ECMM","author":"Tofas PV","year":"2002"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2005.01098.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2005.01098.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:29:07Z","timestamp":1696879747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2005.01098.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,13]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1111\/j.1439-0507.2005.01098.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2005.01098.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,13]]}}}