{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:47:42Z","timestamp":1761947262234},"reference-count":22,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2005,3,29]],"date-time":"2005-03-29T00:00:00Z","timestamp":1112054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die \u00d6sophagusperforation hat eine hohe Letalit\u00e4tsrate, welche zwischen 7 und 49% schwankt. Im untersuchten Kollektiv aus den Jahren 1986 bis 2003 war die hohe Letalit\u00e4tsrate von 28% vorwiegend durch septische Komplikationen wie Mediastinitiden und Pneumonien verursacht. In den mikrobiologischen Untersuchungen unterschiedlicher Lokalisationen und Sekrete wurden bei 28% der Patienten (<jats:italic>n<\/jats:italic>\u2003=\u200316) Pilze nachgewiesen. Im Vergleich zum Gesamtkollektiv f\u00fchrte der Pilzbefall zu einer erh\u00f6hten Letalit\u00e4t um 50%. Die invasive \u00f6sophageale Candidose kann ihrerseits Ursache einer \u00d6sophagusperforation sein. Begleitende Pilzinfektionen entstehen bei \u00d6sophagusperforationen durch das Einbrechen der Perforation in sterile Kompartimente oder durch h\u00e4matogene und lymphogene Ausbreitung bis hin zur Sepsis. Bei unkompliziertem Krankheitsverlauf ist eine antimykotische Therapie nicht erforderlich. Vom Anfang der Behandlung an sollte ein mikrobiologisches Monitoring erfolgen, insbesondere des intraoperativen Befundes. Je nach Risikofaktoren und klinischem Verlauf der Patienten muss mit einer antimykotischen Therapie reagiert werden. Besondere Bedeutung kommt einer chirurgischen Sanierung und einer suffizienten Drainage der beteiligten Kompartimente wie Pleura und Mediastinum zu.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2005.01110.x","type":"journal-article","created":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T08:05:09Z","timestamp":1112169909000},"page":"41-45","source":"Crossref","is-referenced-by-count":7,"title":["Erschwerter Verlauf von \u00d6sophagusperforationen durch Pilzinfektion"],"prefix":"10.1111","volume":"48","author":[{"given":"T.","family":"Jungbluth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kujath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010P.","family":"Bruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(90)90082-H"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)90294-E"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00188486"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780519"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00377-W"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2002.00251.x"},{"key":"e_1_2_5_8_2","first-page":"105","article-title":"Das Boerhaave\u2010Syndrom","volume":"124","author":"Sch\u00e4r B","year":"1994","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2000.00089.x"},{"key":"e_1_2_5_10_2","first-page":"416","article-title":"Intramural rupture and intramural hematoma of the esophagus: 3 case reports and literature review","volume":"122","author":"Criblez D","year":"1992","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.4.8456662"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(84)80082-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2000.108922"},{"key":"e_1_2_5_14_2","first-page":"3257","article-title":"Spontaneus esophageal perforation related to fungal esophagitis","volume":"133","author":"Altorjay A","year":"1992","journal-title":"Orv Hetil"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)01144-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2003.00762.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04343-6"},{"key":"e_1_2_5_18_2","first-page":"417","article-title":"Die Bedeutung von Candida albicans beim komplizierten Ulcus ventriculi et duodeni","author":"Kujath P","year":"1994","journal-title":"Langenbeck Arch Chir"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199510000-00041"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(03)00129-1"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014644"},{"key":"e_1_2_5_22_2","first-page":"78","volume-title":"Mykosen in der operativen Medizin","author":"Schweigart U","year":"1998"},{"key":"e_1_2_5_23_2","first-page":"52","volume-title":"Mykosen in der operativen Medizin","author":"Duswald KH","year":"1998"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2005.01110.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2005.01110.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T10:49:12Z","timestamp":1695811752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2005.01110.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,30]]},"references-count":22,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1439-0507.2005.01110.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2005.01110.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,30]]}}}