{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:21:35Z","timestamp":1780431695561,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T00:00:00Z","timestamp":1130198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fifty\u2010six patients with cerebral zygomycosis (mucormycosis) were seen during the period 1971\u20132001 in two tertiary care hospitals located in south India with tropical climate and catering to neurological diseases. Forty\u2010four patients had rhinocerebral and twelve patients had isolated central nervous system (CNS) zygomycosis. Of these, ten were culture proven (<jats:italic>Rhizopus oryzae<\/jats:italic> in eight and <jats:italic>Mucor<\/jats:italic> in two); 30 were diagnosed as probable and 16 were diagnosed possible; mixed infections were seen in three patients. Diabetes mellitus was the predisposing condition in a majority (31\/44) of patients with the rhinocerebral form of zygomycosis. The tissue obtained at biopsy\/autopsy in either form showed necrotic\/infarcted tissue with neutrophilic infiltration with broad non\u2010septate hyphae showing irregular branching. The outcome was poor despite surgical excision and antifungal therapy. The high concentration of spores in a mouldy environment, the bird population and improper disposal of hospital waste may facilitate healthy hosts presenting with primary CNS disease.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2005.01167.x","type":"journal-article","created":{"date-parts":[[2005,10,25]],"date-time":"2005-10-25T12:06:00Z","timestamp":1130241960000},"page":"396-407","source":"Crossref","is-referenced-by-count":77,"title":["Cerebral zygomycosis"],"prefix":"10.1111","volume":"48","author":[{"given":"C.","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mahadevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Laxmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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