{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:20:53Z","timestamp":1761128453447},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In the USA, &gt;50% of candidemia episodes occur in medical or surgical intensive care units (SICU). However, studies focused on patterns and rationale for antifungal use are lacking. The objective of this study was to evaluate systemic antifungal usage in SICU patients. Retrospective audit of SICU patients receiving antifungal therapy from four American hospitals. Medical records were reviewed for demographics, hospital variables, microbiology results, antifungal regimens and indications for therapy. A total of 2411 patient\u2010days of antifungal use were evaluated in 225 patients. Fluconazole was the most frequently prescribed antifungal (1846 patient\u2010days) followed by amphotericin B deoxycholate (251 patient\u2010days), lipid formulations of amphotericin B (201 patient\u2010days), itraconazole (71 patient\u2010days), and caspofungin (42 patient\u2010days). Antifungals were prescribed empirically (44%), for preemptive therapy in critically ill patients colonised with <jats:italic>Candida<\/jats:italic> (43%), or for candidiasis (12%). <jats:italic>Candida<\/jats:italic> species were recovered from 98% of patients with positive fungal cultures most commonly from pulmonary (53%) or urinary sources (17%). Fluconazole is the most frequently prescribed antifungal agent in SICUs and is most often prescribed for empiric or preemptive indications. Research efforts to identify patients who warrant preemptive antifungal therapy for invasive candidiasis could dramatically change antifungal prescribing patterns in the SICU.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2006.01222.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T16:59:27Z","timestamp":1145984367000},"page":"226-231","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of antifungals in the surgical intensive care unit: a multi\u2010institutional study"],"prefix":"10.1111","volume":"49","author":[{"given":"Kevin W.","family":"Garey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda M.","family":"Neuhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Bearden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan P.","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layne O.","family":"Gentry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199905000-00001"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050552"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/JCM.37.3.531-537.1999","article-title":"Trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital","volume":"37","author":"Berrouane YF","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200208000-00003"},{"key":"e_1_2_7_6_2","volume-title":"Hospital Statistics 2001 Edition","author":"American Hospital Association","year":"2000"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161001-00002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000147726.62304.7F"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/380796"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00831-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/380637"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1422"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091182.93122.8e"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1131"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(95)00010-0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.2.303"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/338404"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363200-00008"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2006.01222.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2006.01222.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:05:20Z","timestamp":1695776720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2006.01222.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,25]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1439-0507.2006.01222.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2006.01222.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,25]]}}}