{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:15:29Z","timestamp":1783692929184,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Luliconazole is a newly developed imidazolyl antifungal agent. A randomised double\u2010blind comparative study was designed to assess the efficacy and safety of 1% luliconazole cream (group A), 0.5% cream (group B) and 0.1% cream (group C), in tinea pedis (interdigital type and plantar type), when used once daily for 2\u2003weeks. Follow\u2010ups were performed at 4\u2003weeks after the end of topical treatment. A total of 241 patients were enrolled and 213 patients were evaluated for efficacy. Rates of improvement of skin lesions in the A, B and C groups assessed at week 4 were 90.5%, 91.0% and 95.8%, respectively. Rates of mycological cure (negative result of microscopy) in the A, B and C groups assessed at week 4 were 79.7%, 76.1%, 72.2% and at week 6 (at 4\u2003weeks after the end of topical treatment) were 87.7%, 94%, 88.9%, respectively. For the mycological effect on tinea pedis of the interdigital type at 2\u2003weeks, the negative conversion of fungi showed a concentration\u2010dependent relationship and indicated a difference in tendency statistically 81.1% (1%\u2013 treatment), 62.9% (0.5%\u2013 treatment), 58.3% (0.1%\u2013 treatment) (Fisher's exact test, <jats:italic>P<\/jats:italic>\u2003=\u20030.079) and there was a trend between three groups by Cochran\u2013Mantel\u2013Haenszel method (<jats:italic>P<\/jats:italic>\u2003=\u20030.038). The incidence of adverse events in which a causal relationship to this drug could not be ruled out was low (2.6%). All of the adverse events were mild in severity and insignificant clinically.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2006.01305.x","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T22:58:09Z","timestamp":1161039489000},"page":"35-40","source":"Crossref","is-referenced-by-count":18,"title":["Dose\u2010finding comparative study of 2\u2003weeks of luliconazole cream treatment for tinea pedis \u2013 comparison between three groups (1%, 0.5%, 0.1%) by a multi\u2010center randomised double\u2010blind study"],"prefix":"10.1111","volume":"50","author":[{"given":"Shinichi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeji","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Takiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutaro","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saburo","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideoki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178285380451"},{"key":"e_1_2_6_3_2","first-page":"546","article-title":"In vitro studies of a new antimycotic, bifonazole, in comparison with clotrimazole and miconazole","volume":"33","author":"Yamaguchi H","year":"1983","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198938020-00004"},{"key":"e_1_2_6_5_2","first-page":"847","article-title":"Antifungal activity of the new agent lanoconazole in two tinea models","volume":"41","author":"Ohmi T","year":"1991","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6547247"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1128\/AAC.34.11.2250","article-title":"Effects of butenafine hydrochloride. 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