{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:15:45Z","timestamp":1792696545895,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T00:00:00Z","timestamp":1169078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Flutrimazole is an imidazole derivative that has been proven to be efficient in superficial skin fungal infections. The aim of this randomised double\u2010blind study was to compare for the first time, the efficiency and safety of flutrimazole 1% shampoo <jats:italic>versus<\/jats:italic> ketoconazole 2% shampoo in the treatment of tinea versicolor. Study population consisted of 60 patients with pityriasis versicolor diagnosed clinically and through direct microscopy and culture. Patients were randomly assigned to two groups: one instructed to apply flutrimazole shampoo 1% and one instructed to apply ketoconazole shampoo 2% both on head and body for 14\u2003days. Patients were re\u2010evaluated 14\u2003days after the end of treatment clinically and through direct microscopy and culture. Twenty\u2010one of 26 patients (80.8%) in the ketoconazole and 22 of 29 patients (75.9%) in the flutrimazole group had both visual healing and negative mycological evaluation. Comparison of the response between the two groups with the Yates\u2019 corrected chi\u2010square was found statistically not significant (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2003=\u20030.19, d.f.\u2003=\u20031, <jats:italic>P<\/jats:italic>\u2003=\u20030.91). None of the patients in the two groups reported any adverse effects. Fourteen (53%) patients in the ketoconazole group and 23 (79%) in the flutrimazole group assessed the shampoos as cosmetically acceptable regarding texture, smell and foam properties. Flutrimazole shampoo 1% appears to present efficacy comparable with ketoconazole 2% in the treatment of tinea versicolor.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2006.01352.x","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T14:46:01Z","timestamp":1169131561000},"page":"193-195","source":"Crossref","is-referenced-by-count":6,"title":["Flutrimazole shampoo 1%<i>versus<\/i> ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double\u2010blind comparative trial"],"prefix":"10.1111","volume":"50","author":[{"given":"D.","family":"Rigopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gregoriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kontochristopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ifantides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katsambas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00039-1"},{"key":"e_1_2_5_3_2","first-page":"836","article-title":"In vitro and in vivo studies with flutrimazole, a new imidazole derivative with antifungal activity","volume":"42","author":"Garcia Rafanell J","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.01047.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00400.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246720"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00520.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00070.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00504.x"},{"key":"e_1_2_5_10_2","first-page":"859","article-title":"Local and systemic tolerance of flutrimazole skin creams following single and repeated topical application in healthy volunteers","volume":"42","author":"Izquierdo I","year":"1992","journal-title":"Arzneimittelforschung"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2006.01352.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2006.01352.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T14:43:46Z","timestamp":1696949026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2006.01352.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,18]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1439-0507.2006.01352.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2006.01352.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,18]]}}}