{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T19:52:45Z","timestamp":1713815565051},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,7,29]],"date-time":"2007-07-29T00:00:00Z","timestamp":1185667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Lacazia loboi<\/jats:italic>, the aetiological agent of lacaziosis (Jorge Lobo's disease), is an uncultivated anomalous fungal microbe closely related to <jats:italic>Paracoccidioides brasiliensis<\/jats:italic>, both restricted Latin American Pathogens. Early reports suggesting that <jats:italic>L. loboi<\/jats:italic> had been isolated in pure culture from cases of lacaziosis, only added more confusion to the already confusing aetiology of this disease. These strains were later identified as unusual contaminants and some of them as <jats:italic>P. brasiliensis<\/jats:italic>. Recent phylogenetic analysis grouped <jats:italic>L. loboi<\/jats:italic> as the sister taxon to <jats:italic>P. brasiliensis<\/jats:italic>, thus it was postulated that the original <jats:italic>P. brasiliensis<\/jats:italic> strains recovered from cases of lacaziosis, could be the aetiological agent of the disease. Using molecular methodologies, we investigated the archival <jats:italic>P. brasiliensis<\/jats:italic> isolate No. 525 from a case of lacaziosis, as well as other archival isolates, identified earlier as common contaminants, all recovered from similar cases of the disease. Phylogenetic analysis, using the 18S small subunit rDNA sequences of these isolates showed that strain No. 525 was a typical <jats:italic>P. brasiliensis<\/jats:italic> isolate and the other studied strains were indeed contaminants. This study unequivocally indicates that the aetiological agent of lacaziosis is yet to be cultured.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2007.01418.x","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T02:33:33Z","timestamp":1185762813000},"page":"470-474","source":"Crossref","is-referenced-by-count":11,"title":["Molecular study of archival fungal strains isolated from cases of lacaziosis (Jorge Lobo's disease)"],"prefix":"10.1111","volume":"50","author":[{"given":"Raquel","family":"Vilela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Eduardo Costa","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane N.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalina","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonel","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","volume-title":"Doen\u00e7a de Jorge L\u00f4bo","author":"Lacaz Cda S","year":"1986"},{"key":"e_1_2_6_3_2","first-page":"763","article-title":"Um caso de blastomicose, producido por uma esp\u00e9cie nova. Encontrada em Recife","volume":"1","author":"L\u00f4bo J","year":"1931","journal-title":"Rev Med Pernambuco, Brasil"},{"key":"e_1_2_6_4_2","first-page":"5","article-title":"Blastomicosis \u2018\u2018tipo Jorge L\u00f4bo\u2019\u2019","volume":"24","author":"De Almeida FP","year":"1948","journal-title":"An Fac Med S Paulo, Brasil"},{"key":"e_1_2_6_5_2","first-page":"151","article-title":"Lobomycosis: nomenclature de su agente (revisi\u00f3n cr\u00edtica)","volume":"3","author":"Borelli D","year":"1968","journal-title":"Med Cutanea (Venezuela)"},{"key":"e_1_2_6_6_2","first-page":"1","volume-title":"Taxonomy of Jorge Lobo's Disease Fungus","author":"Ciferri R","year":"1956"},{"key":"e_1_2_6_7_2","first-page":"703","volume-title":"Fonseca\u2010Filho O da Prasitos e Doen\u00e7as parasit\u00e1rias do Home. v. 1","author":"Fonseca\u2010Filho O","year":"1943"},{"key":"e_1_2_6_8_2","first-page":"225","article-title":"Estudo de culturas isoladas de blastomicose queloidiforme (doen\u00e7a de Jorge L\u00f4bo). Denomina\u00e7\u00e3o ao seu agente etiol\u00f3gico","volume":"13","author":"Fonseca OJdeM","year":"1971","journal-title":"Rev Inst Med Trop S Paulo, Brasil"},{"key":"e_1_2_6_9_2","first-page":"47","article-title":"Aspergillus. Sorpresas en micopatologia","volume":"3","author":"Borelli D","year":"1958","journal-title":"Bol Venez Lab Clin"},{"key":"e_1_2_6_10_2","first-page":"234","volume-title":"The Genus Aspergillus","author":"Raper KB","year":"1965"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.1.309-314.2001"},{"key":"e_1_2_6_12_2","first-page":"276","volume-title":"Pathogenic Fungi. Structural Biology and Taxonomy","author":"Mendoza L","year":"2004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj008"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3657-3661.2005"},{"key":"e_1_2_6_15_2","first-page":"147","article-title":"Contribui\u00e7\u00e3o para o conhecimento das granulomatoses blastomycosides. O agente etiol\u00f3gico da doen\u00e7a de Jorge L\u00f4bo","volume":"48","author":"Fonseca\u2010Filho O","year":"1940","journal-title":"Rev Med Cirug Brasil"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2307\/3760969"},{"key":"e_1_2_6_17_2","first-page":"273","article-title":"Infec\u00e7\u00e3o experimental de animais pela Glenosporella loboi Fonseca & Le\u00e3o, 1940","volume":"33","author":"Ar\u00eaa\u2010Le\u00e3o AE","year":"1948","journal-title":"Hospital (Rio de Janeiro, Brasil)"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.6.2031-2033.1999"},{"key":"e_1_2_6_19_2","first-page":"120","article-title":"Blastomicose queloidiforme. Doen\u00e7a de Jorge L\u00f4bo","volume":"11","author":"L\u00f4bo J","year":"1966","journal-title":"J Bras Med"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2007.01418.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2007.01418.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:38:42Z","timestamp":1696880322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2007.01418.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,29]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1111\/j.1439-0507.2007.01418.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2007.01418.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,29]]}}}