{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:01:04Z","timestamp":1783036864565,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Histoplasmosis occurs in approximately 5% of acquired immunodeficiency syndrome (AIDS) patients in endemic areas and often evolves to a disseminated picture if diagnosis is delayed and\/or CD4 count falls below 150 cells\u2003\u00d7\u2003mm<jats:sup>3<\/jats:sup> without high active antiretroviral therapy (HAART). This report presents clinical features of patients with histoplasmosis admitted from 1992 to 2005. Of the 57 individuals, 45 (79%) were male, aged 20\u201340\u2003years; 30 (52.6%) presented histoplasmosis together with HIV diagnosis and 35 (61.4%) referred illness course up to 4\u2003weeks. Fever, hepatomegaly and\/or splenomegaly, dyspnea and skin lesions were noticed in 50 (87.7%), 38 (66.7%), 30 (52.6%) and 25 (43.9%) patients respectively. High levels of lactic acid dehydrogenase, X\u2010ray lung interstitial pattern, pancytopenia and CD4 count &lt;100 cells\u2003\u00d7\u2003mm<jats:sup>3<\/jats:sup> were observed in 48 (84.2%), 35 (66%), 34 (59.6%) and 33 (94%) patients respectively. Mycological diagnosis was performed by one or more methods in all patients. Thirty nine (68.4%) received amphotericin B and\/or itraconazole. A cure rate was observed in 76.9% and nine (23.1%) died early during therapy. Otherwise death occurred in 18 (31.6%) before diagnosis was completed. Despite free HAART disposal in public Brazilian health services, histoplasmosis still occurs as the first AIDS baseline condition in patients without antiretroviral therapy, many of whom are not receiving any medical care for HIV infection.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2007.01459.x","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T23:05:11Z","timestamp":1193699111000},"page":"136-140","source":"Crossref","is-referenced-by-count":37,"title":["Disseminated histoplasmosis in acquired immunodeficiency syndrome patients in Uberaba, MG, Brazil"],"prefix":"10.1111","volume":"51","author":[{"given":"Delio Jos\u00e9","family":"Mora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Tadeu","family":"Barbosa dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Le\u00f3n","family":"Silva\u2010Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"929","article-title":"Histoplasmosis","volume":"117","author":"Goodwin RA","year":"1978","journal-title":"Am Rev Resp Dis"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-3-331"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199011000-00004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198107000-00001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-680"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198311000-00010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.143.7.1495"},{"key":"e_1_2_6_9_2","first-page":"373","article-title":"Revision of the case definition of acquired immunodeficiency syndrome for national reporting\u2010United States","volume":"34","author":"Centers for Disease Control (CDC)","year":"1985","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1086\/513653","article-title":"Prospective study of histoplasmosis in patients infected with human immunodeficiency virus: incidence, risk factors, and pathophysiology","volume":"24","author":"McKinsey DS","year":"1997","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/319756"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/313824"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80334-6"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/mmy.38.s1.259.267","article-title":"Mycoses in AIDS","volume":"38","author":"Dupont B","year":"2000","journal-title":"Med Mycol"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/345724"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/379770"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/428842"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.3.623"},{"key":"e_1_2_6_19_2","first-page":"5","article-title":"Histoplasmosis Diseminada em Pacientes com SIDA, su evolution y tratamiento","volume":"14","author":"Negroni R","year":"1991","journal-title":"Rev Arg Micologia"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-5520(20)30570-5","article-title":"HIV infection and AIDS in Latin America. 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