{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:42:21Z","timestamp":1773283341020,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A study of candidaemia in neonatal intensive care unit (NICU) over a 12\u2010year period (1995\u20132006) taking into consideration demographic variables, risk factors, aetiological <jats:italic>Candida<\/jats:italic> species and therapeutic outcomes is presented. The yeast isolates were identified by VITEK2 yeast identification system and antifungal susceptibility was determined by E\u2010test. Of 4815 neonates admitted in NICU, 182 cases of candidaemia were detected with an overall prevalence of 4.0% and crude mortality of 27.7%. The annual rate of candidaemia per 1000 admissions was the highest in 1997 (84 cases) and the lowest in 2004 (10 cases). Of the 112 assessable candidaemia cases, 78 (70%) occurred in very low birth weight neonates (\u22641500\u2003g), 65 (58%) were born with gestational age of \u226430\u2003weeks. The main identifiable risk factors were use of \u22652 antibiotics (87%), total parenteral nutrition for &gt;5\u2003days (82%), placement of central venous catheter (78%) and prior colonisation with <jats:italic>Candida<\/jats:italic> species (54%). <jats:italic>Candida albicans<\/jats:italic> and non\u2010<jats:italic>albicans Candida<\/jats:italic> species accounted for 43% and 57% of candidaemia cases, respectively, and <jats:italic>C. parapsilosis<\/jats:italic> emerged as a predominant species. No fluconazole resistance was observed in <jats:italic>C. albicans<\/jats:italic> and <jats:italic>C. parapsilosis<\/jats:italic> isolates. This is the first comprehensive study on the epidemiology of neonatal candidiasis in Kuwait.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2008.01637.x","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T19:00:03Z","timestamp":1246647603000},"page":"518-523","source":"Crossref","is-referenced-by-count":22,"title":["Neonatal candidaemia in Kuwait: a 12\u2010year study of risk factors, species spectrum and antifungal susceptibility"],"prefix":"10.1111","volume":"52","author":[{"given":"Noura","family":"Al\u2010Sweih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziauddin","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. V.","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0672-5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70191-9"},{"key":"e_1_2_6_4_2","first-page":"153","article-title":"Neonatal candidiasis","volume":"31","author":"Khan ZU","year":"1999","journal-title":"Kuwait Med J"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200302000-00016"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199806000-00014"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.34"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81375-7"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198702000-00009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-970078"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198611000-00016"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/520277"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/520194"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01492.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2000.12.4.332"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.2.735-741.2003"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0638"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/fnn.2006.097758"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000054242"},{"key":"e_1_2_6_20_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standards","author":"Clinical Laboratory Standards Institute (formerly National Committee for Clinical Laboratory Standards)","year":"2002"},{"key":"e_1_2_6_21_2","volume-title":"Etest Technical Guide 4b: Antifungal Susceptibility Testing of Yeasts","author":"AB BIODISK","year":"1994"},{"key":"e_1_2_6_22_2","volume-title":"Quality Control Minimal Inhibitory Concentration (MIC) Limits for Broth Microdilution and MIC Interpretive Breakpoints (Appendix C) (M27\u2010S2)","author":"Clinical Laboratory Standards Institute","year":"2006"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3149-3154.2003"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40008"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1996"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.4.1829-1835.2005"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.3.756"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200004000-00011"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.02.021"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210699"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3254-3259.2001"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.747-751.2000"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46817-0"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00222-07"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1054\/drup.1998.0059"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2008.01637.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2008.01637.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:53:16Z","timestamp":1696942396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2008.01637.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,5]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1111\/j.1439-0507.2008.01637.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2008.01637.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,5]]}}}