{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:27:18Z","timestamp":1761128838158},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T00:00:00Z","timestamp":1274227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There are no previous studies on the comparative virulence of <jats:italic>Candida dubliniensis<\/jats:italic> with other non\u2010<jats:italic>albicans<\/jats:italic> species. The aim of this study was to compare the virulence and infection kinetics of <jats:italic>C. dubliniensis<\/jats:italic> and other species. <jats:italic>Candida albicans<\/jats:italic>, <jats:italic>C. dubliniensis<\/jats:italic>, <jats:italic>Candida tropicalis<\/jats:italic> and <jats:italic>Candida krusei<\/jats:italic> (reference strains) were inoculated intravenously in mice. For infection kinetics evaluation, a group of five animals were sacrificed after 6\u2003h, 3, 7, 14 and 21\u2003days. Microbiological evaluations (liver, spleen, kidneys, lungs and brain) and histopathological examination of the kidney were performed. The results of virulence evaluation were analysed using Kaplan\u2013Meier survival analysis (5%). <jats:italic>Candida dubliniensis<\/jats:italic>\u2010inoculated mice survived for longer periods compared with those with <jats:italic>C. albicans<\/jats:italic> (<jats:italic>P\u2003<\/jats:italic>=\u20030.005). No differences were detected in relation to <jats:italic>C. tropicalis<\/jats:italic> (<jats:italic>P\u2003<\/jats:italic>=\u20030.326) and <jats:italic>C. krusei<\/jats:italic> (<jats:italic>P\u2003<\/jats:italic>=\u20030.317). Most of the organs were persistently colonised by <jats:italic>C. albicans<\/jats:italic> and <jats:italic>C. dubliniensis<\/jats:italic> even by day 21. Tendency of <jats:italic>C. krusei<\/jats:italic> clearance was observed in all organs. Fungal masses and renal lesions were observed after inoculation of <jats:italic>C. albicans<\/jats:italic>, <jats:italic>C. dubliniensis<\/jats:italic> and <jats:italic>C. tropicalis<\/jats:italic>. Within the limits of the study, data on survival rate and dissemination capacity suggest that <jats:italic>C. dubliniensis<\/jats:italic> is less virulent than <jats:italic>C. albicans<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2010.01899.x","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T03:37:20Z","timestamp":1274326640000},"source":"Crossref","is-referenced-by-count":12,"title":["Experimental systemic virulence of oral <i>Candida dubliniensis<\/i> isolates in comparison with <i>Candida albicans<\/i>, <i>Candida tropicalis<\/i> and <i>Candida krusei<\/i>"],"prefix":"10.1111","volume":"54","author":[{"given":"Cristiane Yumi","family":"Koga\u2010Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson Yukio","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9lia Aparecida","family":"de Paiva Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e1ssia Castro","family":"Vasconcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Olavo","family":"Cardoso Jorge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin Rodarte","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Falchete","family":"do Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Balducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00801-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000200019"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199705000-00002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1128\/JCM.38.2.902-904.2000","article-title":"Growth competition between Candida dubliniensis and Candida albicans under broth and biofilm growing conditions","volume":"38","author":"Kirkpatrick WR","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-1356(03)00240-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2006.11.014"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/589298"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/428846"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/432943"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.04.003"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2005.00107.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1128\/JCM.36.10.2869-2873.1998","article-title":"Prevalence of Candida dubliniensis isolates in a yeast stock collection","volume":"6","author":"Odds FC","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-4-829"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.3.249.257"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-002-2131-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/513615"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.1151"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0339-8"},{"key":"e_1_2_6_20_2","first-page":"28","article-title":"Isolation of Candida dubliniensis in a teenager with denture stomatitis","volume":"10","author":"Mosca CO","year":"2005","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242004000100015"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.49.3.571-575.1985"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00028-08"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2010.01899.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2010.01899.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T04:05:43Z","timestamp":1697256343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2010.01899.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1439-0507.2010.01899.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2010.01899.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}