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Among posaconazole advantages are the relatively low potential of cross\u2010resistance with other azoles, few drug interactions compared with other azoles and its activity against Zygomycetes. Randomised, double\u2010blind trials have shown that posaconazole is effective for prophylaxis against invasive fungal infections (IFI), especially aspergillosis, in high\u2010risk patients. Results of Phase III clinical trials and case\/series reports indicate that posaconazole is effective in treating oesophageal candidiasis, including azole\u2010refractory disease, and other IFI refractory to standard antifungal therapies. To date, posaconazole has appeared to be well tolerated even in long\u2010term courses; it has an excellent safety profile with gastrointestinal disturbances being the most common adverse events reported. The dose of posaconazole is 200\u2003mg three times daily for prophylaxis, 800\u2003mg daily in two or four divided doses for the treatment of IFI and 100\u2003mg daily (200\u2003mg loading dose) for the treatment of oropharyngeal candidiasis. On the basis of early clinical experience, it appears that posaconazole will be a valuable aid in the management of life\u2010threatening fungal infections.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2011.02061.x","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T07:22:45Z","timestamp":1310973765000},"page":"110-122","source":"Crossref","is-referenced-by-count":30,"title":["Posaconazole: when and how? 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