{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:25:26Z","timestamp":1789208726842,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T00:00:00Z","timestamp":1318550400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Prosthetic joint infections (PJI) are rarely due to fungal agents and if so they are mainly caused by <jats:italic>Candida<\/jats:italic> strains. This case represents a PJI caused by a multi\u2010drug resistant <jats:italic>Pseudallescheria apiosperma<\/jats:italic>, with poor <jats:italic>in vivo<\/jats:italic> response to itraconazole and voriconazole. This case differs also by the way of infection, since the joint infection did not follow a penetrating trauma. In the majority of cases, <jats:italic>Scedosporium<\/jats:italic> extremity infections remain local in immunocompetent individuals. We report a persistent joint infection with multiple therapeutic failures, and subsequent amputation of the left leg. Detailed clinical data, patient history, treatment regime and outcome of a very long\u2010lasting (&gt;4\u2003years) <jats:italic>P. apiosperma<\/jats:italic> prosthetic knee infection in an immunocompetent, 61\u2010year\u2010old male patient are presented with this case. The patient was finally cured by the combination of multiple and extensive surgical interventions and prolonged antifungal combination therapy with voriconazole and terbinafine.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2011.02107.x","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T11:28:05Z","timestamp":1318591685000},"page":"22-27","source":"Crossref","is-referenced-by-count":27,"title":["Severe prosthetic joint infection in an immunocompetent male patient due to a therapy refractory <i>Pseudallescheria apiosperma<\/i>"],"prefix":"10.1111","volume":"54","author":[{"given":"M.","family":"Lackner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"De Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Eygendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G. F.","family":"Wintermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Kluytmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,14]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"494","article-title":"Fungal infection of prosthetic joints: a report of two cases","volume":"10","author":"Goodman JS","year":"1983","journal-title":"J Rheumatol"},{"key":"e_1_2_5_3_2","first-page":"133","article-title":"Infection of a total knee arthroplasty by Candida parapsilosis. A case report of successful treatment by joint reimplantation with a literature review","volume":"9","author":"Hennessy MJ","year":"1996","journal-title":"Am J Knee Surg"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0933-7407.2003.00928.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01960889"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2001.21505"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.017"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.07.010"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2169\/naika.78.432"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0255-0857(21)02535-4","article-title":"Prosthetic valve endocarditis caused by Scedosporium apiospermum","volume":"23","author":"Verghese S","year":"2005","journal-title":"Indian J Med Microbiol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.6.803"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1997.tb01062.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.5.731"},{"key":"e_1_2_5_14_2","first-page":"674","article-title":"Successful treatment of Scedosporium apiospermum suppurative arthritis with itraconazole","volume":"9","author":"Piper JP","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693780902939695"},{"key":"e_1_2_5_16_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard","author":"Clinical and Laboratory Standards Institute"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00596.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/JCM.36.5.1436-1438.1998","article-title":"Use of voriconazole in treatment of Scedosporium apiospermum infection: case report","volume":"36","author":"Girmenia C","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00636.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.954-958.2001"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200212000-00004"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.4009-4011.2004"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.2.147"},{"issue":"1","key":"e_1_2_5_24_2","first-page":"83","article-title":"Scedosporium apiospermum brain abscess treated with surgery and voriconazole. Case report","volume":"103","author":"Chakraborty A","year":"2005","journal-title":"J Neurosurg"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1233-2"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.106-117.2003"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00878.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0877-z"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01575117"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1995.tb00066.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2004.17.6.9"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199302000-00020"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/426445"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-003-0652-3"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780310001631322"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802695470"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02491.x"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/714043905"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2011.02107.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2011.02107.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:48:40Z","timestamp":1694512120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2011.02107.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":37,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1439-0507.2011.02107.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2011.02107.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}