{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:38:28Z","timestamp":1773319108620,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>During antifungal evaluation of various plant extracts, free and bound flavonoids of <jats:italic>Piper betle<\/jats:italic> were found to be most effective as an antidermatophytic against human pathogenic dermatophytes <jats:italic>Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum gypseum<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic>. Dermatophytic fungi cause both superficial and internal mycoses. These mycoses, although normally not lethal, are unpleasant and difficult to cure and cause considerable financial losses. Earlier workers prove that allopathic drugs are still found effective against dermatomycoses, but these drugs could not be accepted as a routine treatment for every case, because they are expensive and require long treatment. It is almost unaffordable by middle and lower class people. In view of such prospects and constraints, our aim was to explore more new compounds of plant origin for controlling dermatophytic infections. Author explored water, methanolic and flavonoid extracts for screening as antidermatophytic agent. Plant extracts that showed good results <jats:italic>in vitro<\/jats:italic> were selected for clinical studies. The study may give cheaper treatment for medium and lower class patients suffering with tinea and may provide them much relief. Well\u2010established paper disc method was used for the screening of different extracts of their antidermatophytic activity. Moreover, it did not exhibit any adverse side effect on mammalian skin. Flavonoids in the form of ointment Pi be I and Pi be II were subjected to topical testing on patients attending out patients department of S.M.S. Hospital, Jaipur, India. Patients were diagnosed as tinea corporis, tinea capitis, tinea manum or tinea pedis. All patients showed positive potassium hydroxide (KOH) results at the beginning of trial. Patients between the ages of 3\u2003months to 58\u2003years were enrolled. At the end of treatment, while 64% of patients cured completely, 24% showed significant improvement and 12% showed little improvement from the disease. Allopathic treatment took 4\u20138\u2003weeks when compared with only 1\u20135\u2003weeks taken by Pi be I and Pi be II ointments. The ointment, thus not only showed maximum affectivity but was also found to be a better and cost effective alternative to allopathic drug for tinea infections. The acceptability of alternative medicines, particularly herbal medicines, has now become a critical need of the times.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2011.02120.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T18:07:40Z","timestamp":1316455660000},"page":"339-343","source":"Crossref","is-referenced-by-count":11,"title":["Broad spectrum antidermatophytic drug for the control of tinea infection in human beings"],"prefix":"10.1111","volume":"55","author":[{"given":"Seema","family":"Bhadauria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padma","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Taxonomical, paramedical and physiological studies on fungi causing superficial infection in mammalian species","author":"Iyer SR","year":"1988"},{"key":"e_1_2_5_3_2","first-page":"209","article-title":"Clinicomycological study of Tinea capitis","volume":"62","author":"Kumar V","year":"1996","journal-title":"Indian J Derm Vener Leprol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01751.x"},{"key":"e_1_2_5_5_2","volume-title":"Antimicrobial activity of secondary metabolites from plants","author":"Jain N","year":"2002"},{"key":"e_1_2_5_6_2","first-page":"836","article-title":"Broad spectrum antimycotic drug for the control of fungal infection in human beings","volume":"76","author":"Shahi SK","year":"1999","journal-title":"Curr Sci"},{"key":"e_1_2_5_7_2","volume-title":"Taxonomical, physiological and para clinical studies of fungi causing skin and other infection in human beings","author":"Sharma M","year":"1983"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-2-14"},{"key":"e_1_2_5_9_2","first-page":"839","article-title":"Antimicrobial activity of some medicinal plants against plant and human pathogen","volume":"4","author":"Mahesh B","year":"2008","journal-title":"World J Agric sci"},{"key":"e_1_2_5_10_2","first-page":"178","article-title":"The determination of bacterial sensitivity of antibiotics","volume":"59","author":"Gould JC","year":"1952","journal-title":"Edinb Med J"},{"key":"e_1_2_5_11_2","volume-title":"Treatment of dermatophytic infection by compounds of plant origin","author":"Bhadauria S","year":"2001"},{"key":"e_1_2_5_12_2","first-page":"30","article-title":"Broadspectrum drug for the control of tinea","volume":"85","author":"Jain N","year":"2003","journal-title":"Curr Sci"},{"key":"e_1_2_5_13_2","volume-title":"Roxburgh\u2019s Common Skin Disease","author":"Roxburgh AC","year":"1973"},{"key":"e_1_2_5_14_2","first-page":"157","article-title":"Comparative account of allopathy treatment for tinea","volume":"21","author":"Robert I","year":"1999","journal-title":"J Invest Derm"},{"key":"e_1_2_5_15_2","volume-title":"Control of ringworm infection by the Trachyspermum ammi oil","author":"Dikshit A"},{"key":"e_1_2_5_16_2","first-page":"217","article-title":"Traditional utilization of indigenous plants for the treatment of cold and skin diseases in Puducherry region","volume":"23","author":"Vimalavady A","year":"2010","journal-title":"J Phytol Res"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1439-0507.2011.02120.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1439-0507.2011.02120.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T16:44:35Z","timestamp":1697301875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1439-0507.2011.02120.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,19]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1439-0507.2011.02120.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1439-0507.2011.02120.x","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,19]]}}}