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The peculiarities of the nail apparatus in health and disease lead to difficulties in being able to successfully treat this condition. Hence, the very same antifungals which produce high cure rates in skin infections are rendered less efficacious in nail disease. Low cure rates and high relapse rates even with highly efficacious antifungals have lead to an increasing interest in exploring newer treatment options which can ensure drug penetration, drug persistence, mycological cure and effective prevention of relapse. The current review aims to summarize our current status of knowledge about the treatment options for OM. It also summarizes the newer areas of research especially with respect to devices related therapies; physical measures to enhance penetration through nail; and development and evaluation of synergistic combinations.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02199.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T07:28:43Z","timestamp":1335770923000},"page":"541-551","source":"Crossref","is-referenced-by-count":52,"title":["An update on treatment of 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