{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:06:53Z","timestamp":1788631613228,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recent studies have shown decreased susceptibility of <jats:italic>Candida krusei<\/jats:italic> to amphotericin B (AmB), in addition to its inherent resistance to fluconazole. The susceptibility of <jats:italic>C.\u2003krusei<\/jats:italic> to AmB was studied in the Parasitology\u2013Mycology laboratory of Grenoble Teaching Hospital, France. Between 2003 and 2011, we analysed 200 <jats:italic>C.\u2003krusei<\/jats:italic> isolates from 130 patients. The isolates were mainly collected in intensive care, cardio\u2010thoracic and cancer\/haematology units. Minimum inhibitory concentrations (MICs) were determined by the <jats:italic>E<\/jats:italic>\u2010test method. The modal MIC was 0.5\u2003\u03bcg ml<jats:sup>\u22121<\/jats:sup>; the MIC<jats:sub>50<\/jats:sub> and MIC<jats:sub>90<\/jats:sub> (MICs encompassing 50% and 90% of all isolates tested, respectively) were 0.5\u2003\u03bcg ml<jats:sup>\u22121<\/jats:sup> and 1\u2003\u03bcg ml<jats:sup>\u22121<\/jats:sup>. The Cuzick\u2019s and Kendall\u2019s tests showed a significant increase in MIC values between 2003 and 2011 (<jats:italic>P\u2003<\/jats:italic>=\u20030.001 and <jats:italic>P\u2003<\/jats:italic>\u2264\u20030.001, respectively), regardless of age or gender. No statistical difference was reached with these tests when the first 100 or 50 data were excluded. Despite the increase observed in the first period of the study, our results confirm the low AmB MICs reported in previous studies. However, some authors have recently reported much higher MICs. This discrepancy cannot be explained by method biases and could reflect <jats:italic>C. krusei<\/jats:italic> epidemiological differences among populations.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02200.x","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T04:40:46Z","timestamp":1335156046000},"page":"56-60","source":"Crossref","is-referenced-by-count":4,"title":["Minimum inhibitory concentrations of amphotericin B against <i>Candida krusei<\/i> isolates from a French teaching hospital laboratory: a retrospective study over 8 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