{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T18:59:48Z","timestamp":1776970788774,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Onychomycosis is difficult to cure as this requires eradication of the primary infection and protection of new areas of growth from reinfection. A new topical treatment (K101) has been developed. The aim of this study was to assess the efficacy, safety and tolerability of K101 treatment of distal subungual onychomycosis. This was a 24\u2010week (plus 2\u2010week washout), multicentre, randomised, double\u2010blind, placebo\u2010controlled study in 493 patients with distal subungual onychomycosis (K101, <jats:italic>n<\/jats:italic>\u2003=\u2003346; placebo, <jats:italic>n<\/jats:italic>\u2003=\u2003147), stratified according to degree of nail involvement. More patients with \u226450% nail involvement achieved the primary endpoint (mycological cure after 26\u2003weeks) in the K101 group (27.2%) than placebo (10.4%; <jats:italic>P<\/jats:italic>\u2003=\u20030.0012). Proportions for patients with 51\u201375% involvement were 19.1% for K101 and 7.0% for placebo (not significant). More patients applying K101 than placebo judged that their condition had improved from week\u20032 (<jats:italic>P<\/jats:italic>\u2003=\u20030.0148) to week 24 (<jats:italic>P<\/jats:italic>\u2003=\u20030.0004). No safety issues were identified. K101 provides early visible improvements in nail appearance and a clinically meaningful antifungal activity.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02215.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T11:54:45Z","timestamp":1339415685000},"page":"532-540","source":"Crossref","is-referenced-by-count":20,"title":["Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24\u2010week, double\u2010blind, placebo\u2010controlled 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