{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:11:45Z","timestamp":1698739905882},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Aspergillus fumigatus<\/jats:italic> is an intracellular opportunistic fungus causing invasive pulmonary mycosis, characterised by hyphal invasion and destruction of pulmonary tissue. Th1 cytokines could enhance fungicidal activity. The effects from the combination of interleukin\u201012 (IL\u201012) and IL\u20102 are rarely known in invasive pulmonary aspergillosis infection. To assess the cleaning of <jats:italic>A. fumigatus<\/jats:italic> infection in the pulmonary tissues by IL\u201012 and IL\u20102, interferon\u2010\u03b3 (IFN\u2010\u03b3) was detected in the sera using ELISA, quantification of IFN\u2010\u03b3 mRNA using real\u2010time RT\u2010PCR and lung Colony\u2010forming unit was assayed by cultivation. Morphology was analysed by histopathological examination. Our results showed that IL\u201012 and\/or IL\u20102 could enhance the IFN\u2010\u03b3 expression in the pulmonary tissue, reduce the colony load in the pulmonary tissue and increase the survival rate of mouse. The combination of IL\u201012 and IL\u20102 could assist in increasing the IFN\u2010\u03b3 expression in the pulmonary tissue, but neither reduce colony load in the pulmonary tissue nor increase the survival rate of mouse significantly. It was demonstrated that IL\u201012 and IL\u20102 were strong immunomodulatory cytokines as a prerequisite for protecting the host from infectious agents.<\/jats:p>","DOI":"10.1111\/j.1439-0507.2012.02220.x","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T20:35:31Z","timestamp":1343421331000},"page":"117-122","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin\u201012 and interleukin\u20102 alone or in combination against the infection in invasive pulmonary aspergillosis mouse 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